Gls2 - glutaminase 2 (liver, mitochondrial) Gene

Also Known as GA; GLS; Lga; A330074B06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216456

Summary

Predicted to enable Glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Predicted to act upstream of or within Reactive Oxygen Species metabolic process and regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; limb; nervous system; skeleton; and urinary system. Orthologous to human GLS2 (Glutaminase 2). [provided by Alliance of Genome Resources, Apr 2022]

Gls2 Products (3)

mRNA Protein Name
NM_001033264.3 NP_001028436.2 glutaminase liver isoform, mitochondrial isoform 1 precursor
NM_001285777.1 NP_001272706.1 glutaminase liver isoform, mitochondrial isoform 2
NM_001285779.1 NP_001272708.1 glutaminase liver isoform, mitochondrial isoform 3
Protein Preferred Names Protein Names

glutaminase liver isoform, mitochondrial

  • L-glutaminase

  • L-glutamine amidohydrolase

  • liver mitochondrial glutaminase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-12248 Telaglenastat 99.82% Phase 2
HY-12248A Telaglenastat hydrochloride 98.03% Phase 2
HY-P2760 Glutaminase Control / Phase 2
HY-103671 IPN60090 Inhibitor 98.96% Phase 1
HY-103671A IPN60090 dihydrochloride Inhibitor 99.68% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151434 GLS1 Inhibitor-6 / Unkown
HY-RS05503 GLS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17808 Gls2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24276 Gls2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gls2 NCBI NCBI:27165