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F13B - coagulation factor XIII B chain Gene

Also Known as FXIIIB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2165

About F13B

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:197,038,741-197,067,260 (from NCBI)

This gene has 3 transcripts (splice variants), 250 orthologues, 39 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 37.1).

Summary

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by Thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a Transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

F13B Products (1)

mRNA	Protein	Name
NM_001994.3	NP_001985.2	coagulation factor XIII B chain precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in blood coagulation, fibrin clot formation	IDA IDA: Inferred from direct assay	27363989	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F13B Protein Structure

Sushi

0
200
400
600
661 a.a.

Protein Preferred Names	Protein Names
coagulation factor XIII B chain	TGase

Recombinant F13B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74238	Coagulation factor XIII B/F13B Protein, Human (HEK293, His)	P05160 (E21-T661)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Factor Xiii, B Subunit, Deficiency Of	Factor Xiiib Deficiency Factor Xiii Subunit B Deficiency FA13BD F13 Deficiency Type 1 Type I F13 Deficiency
Factor Xiii Deficiency	Hereditary Factor Xiii Deficiency Disease Deficiency, Laki-Lorand Factor Congenital Factor Xiii Deficiency Fibrin Stabilizing Factor Deficiency Deficiency, Factor Xiii Factor Xiii Deficiency Disease Deficiency Of Factor Xiii Fibrin-Stabilizing Factor Deficiency Factor Xiii Deficiency, Congenital
Thrombophilia Due To Thrombin Defect	Venous Thromboembolism Venous Thrombosis Thrombophilia Due To Factor 2 Defect Thromboembolism THPH1 Thromboembolism, Susceptibility To Venous Thromboembolism, Susceptibility To Venous Thrombosis, Protection Against Prothrombin-Related Thrombophilia Hyperprothrombinemia Venous Thrombosis, Susceptibility To Thrombophilia 1 Due To Thrombin Defect F2-Related Thrombophilia Factor Ii-Related Thrombophilia Prothrombin 20210g>A Thrombophilia Prothrombin G20210a Thrombophilia Prothrombin Thrombophilia
Thrombosis	Thrombosis Of Blood Vessel
Retinitis Pigmentosa 12	RP12 Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium Rp With Or Without Pprpe Retinitis Pigmentosa-12
Hemarthrosis	Haemarthrosis Of Shoulder Joint Haemarthrosis Of The Ankle And Foot Haemarthrosis Of The Pelvic Region And Thigh Hemarthrosis Involving Ankle And Foot Hemarthrosis Involving Forearm Hemarthrosis Involving Hand Hemarthrosis Involving Lower Leg Hemarthrosis Involving Pelvic Region And Thigh Hemarthrosis Involving Shoulder Region Hemarthrosis Involving Upper Arm Hemarthrosis Of Ankle And/Or Foot Hemarthrosis Of Forearm Hemarthrosis Of Hand Hemarthrosis Of Lower Leg Hemarthrosis Of Shoulder Hemarthrosis Of Shoulder Region Hemarthrosis Of The Ankle And Foot Hemarthrosis Of The Ankle And/Or Foot Hemarthrosis Of The Forearm Hemarthrosis Of The Hand Hemarthrosis Of The Lower Leg Hemarthrosis Of The Pelvic Region And Thigh Hemarthrosis Of The Shoulder Region Hemarthrosis Of The Upper Arm Hemarthrosis Of Upper Arm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04629	F13B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17536	F13b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23993	F13b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	F13B	MGD	MGI:88379
Macaca mulatta	F13B	VGNC	VGNC:72463
Felis catus	F13B	VGNC	VGNC:62022
Bos taurus	F13B	VGNC	VGNC:28681
Canis familiaris	F13B	VGNC	VGNC:40546
Rattus norvegicus	F13B	RGD	RGD:1311668
Others	F13B	NCBI