F13B - coagulation factor XIII B chain Gene

Homo sapiens

Also known as FXIIIB

Gene ID: 2165 | Gene type: protein coding

About F13B

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:197,038,741-197,067,260 (from NCBI)

This gene has 3 transcripts (splice variants), 250 orthologues, 39 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 37.1).

Summary

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by Thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active Enzyme, factor XIIIa, as platelet factor XIII. This Enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

F13B Products(1)

mRNA	Protein	Name
NM_001994.3	NP_001985.2	coagulation factor XIII B chain precursor

F13B Protein Structure

Sushi

0
200
400
600
661 a.a.

Protein Preferred Names

Protein Names

coagulation factor XIII B chain

TGase

Recombinant F13B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74238	Coagulation factor XIII B/F13B Protein, Human (HEK293, His)	P05160 (E21-T661)	≥95%

Related Diseases

Diseases

Alias

Factor Xiii, B Subunit, Deficiency Of

Factor Xiiib Deficiency	Factor Xiii Subunit B Deficiency
FA13BD	F13 Deficiency Type 1
Type I F13 Deficiency

Factor Xiii Deficiency

Hereditary Factor Xiii Deficiency Disease	Deficiency, Laki-Lorand Factor
Congenital Factor Xiii Deficiency	Fibrin Stabilizing Factor Deficiency
Deficiency, Factor Xiii	Factor Xiii Deficiency Disease
Deficiency Of Factor Xiii	Fibrin-Stabilizing Factor Deficiency
Factor Xiii Deficiency, Congenital

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism	Venous Thrombosis
Thrombophilia Due To Factor 2 Defect	Thromboembolism
THPH1	Thromboembolism, Susceptibility To
Venous Thromboembolism, Susceptibility To	Venous Thrombosis, Protection Against
Prothrombin-Related Thrombophilia	Hyperprothrombinemia
Venous Thrombosis, Susceptibility To	Thrombophilia 1 Due To Thrombin Defect
F2-Related Thrombophilia	Factor Ii-Related Thrombophilia
Prothrombin 20210g>A Thrombophilia	Prothrombin G20210a Thrombophilia
Prothrombin Thrombophilia

Thrombosis

Thrombosis Of Blood Vessel

Retinitis Pigmentosa 12

RP12	Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium
Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium	Rp With Or Without Pprpe
Retinitis Pigmentosa-12

Hemarthrosis

Haemarthrosis Of Shoulder Joint	Haemarthrosis Of The Ankle And Foot
Haemarthrosis Of The Pelvic Region And Thigh	Hemarthrosis Involving Ankle And Foot
Hemarthrosis Involving Forearm	Hemarthrosis Involving Hand
Hemarthrosis Involving Lower Leg	Hemarthrosis Involving Pelvic Region And Thigh
Hemarthrosis Involving Shoulder Region	Hemarthrosis Involving Upper Arm
Hemarthrosis Of Ankle And/Or Foot	Hemarthrosis Of Forearm
Hemarthrosis Of Hand	Hemarthrosis Of Lower Leg
Hemarthrosis Of Shoulder	Hemarthrosis Of Shoulder Region
Hemarthrosis Of The Ankle And Foot	Hemarthrosis Of The Ankle And/Or Foot
Hemarthrosis Of The Forearm	Hemarthrosis Of The Hand
Hemarthrosis Of The Lower Leg	Hemarthrosis Of The Pelvic Region And Thigh
Hemarthrosis Of The Shoulder Region	Hemarthrosis Of The Upper Arm
Hemarthrosis Of Upper Arm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04629	F13B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	F13B	MGD	MGI:88379
Macaca mulatta	F13B	VGNC	VGNC:72463
Felis catus	F13B	VGNC	VGNC:62022
Bos taurus	F13B	VGNC	VGNC:28681
Canis familiaris	F13B	VGNC	VGNC:40546
Rattus norvegicus	F13B	RGD	RGD:1311668
Macaca fascicularis	F13B	NCBI
Others	F13B	NCBI