Sry - sex determining region of Chr Y Gene

Also Known as Tdf; Tdy

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21674

Summary

Enables DNA binding activity, bending and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in male sex determination. Acts upstream of or within male gonad development; negative regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including brain; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in 46,XX sex reversal 1; 46,XY sex reversal; and 46,XY sex reversal 1. Orthologous to human SRY (sex determining region Y). [provided by Alliance of Genome Resources, Apr 2022]

Sry Products (1)

mRNA Protein Name
NM_011564.1 NP_035694.1 sex-determining region Y protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
8625802 MGI
enables DNA binding, bending IDA
IDA: Inferred from direct assay
7774816 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22344693 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10410901 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within male gonad development IDA
IDA: Inferred from direct assay
19457926 MGI
involved in male gonad development IDA
IDA: Inferred from direct assay
33004521 MGI
involved in male sex determination IDA
IDA: Inferred from direct assay
33004521 MGI
acts upstream of or within male sex determination IGI
IGI: Inferred from genetic interaction
15879091 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
11869290 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19850934 MGI
involved in sex determination IDA
IDA: Inferred from direct assay
33004521 MGI
acts upstream of or within sex determination IGI
IGI: Inferred from genetic interaction
9486644 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15469996 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
22344693 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sex-determining region Y protein

  • testis determining-Y

  • testis-determining factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13801 SRY Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174539 Human SOX2 mRNA / Unkown
HY-RS21288 Sry Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23830 Sox9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27807 Sry Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sry NCBI NCBI:6736