Terc - telomerase RNA component Gene

Also Known as mTR; mTER

Species: Mus musculus

Gene Type: ncRNA
Gene ID: 21748

Summary

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with Reverse Transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Deregulation of Telomerase expression in somatic cells may be involved in oncogenesis. Telomerase may also participate in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. In contrast with human Telomerase, murine Telomerase is expressed in many normal postnatal somatic tissues. [provided by RefSeq, Jul 2008]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables telomerase activity IMP
IMP: Inferred from mutant phenotype
17982445 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
15235603 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
17554309 MGI
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17554309 MGI
acts upstream of or within positive regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
17982445 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
17554309 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
11381263 MGI
acts upstream of or within telomere maintenance IGI
IGI: Inferred from genetic interaction
15235603 MGI
acts upstream of or within telomere maintenance IMP
IMP: Inferred from mutant phenotype
17145779 MGI
acts upstream of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
17982445 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137817 BCH001 Inhibitor 98.72% Unkown
HY-174537 Human TERT mRNA / Unkown
HY-RS16330 TERC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17417 Terc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23871 Terc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Terc NCBI NCBI:7012