Mgat2 - mannoside acetylglucosaminyltransferase 2 Gene

Also Known as GNT2; CDGS2; GNT-II; GLCNACTII

Species: Mus musculus

Gene Type: protein coding
Gene ID: 217664

About Mgat2

Chromosome 12: 69,230,931-69,233,544 forward strand.GRCm39:CM001005.3

This gene has 1 transcript (splice variant), 178 orthologues and is associated with 40 phenotypes.

Summary

Enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation via asparagine. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; cranium; integumental system; sensory organ; and telencephalon. Used to study congenital disorder of glycosylation type IIa. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Orthologous to human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgat2 Products (1)

mRNA Protein Name
NM_146035.2 NP_666147.1 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IMP
IMP: Inferred from mutant phenotype
12417412 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within protein N-linked glycosylation via asparagine IMP
IMP: Inferred from mutant phenotype
12417412 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mgat2 Protein Structure

MGAT2

MGAT2: pfam05060 (86 - 434)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 442 a.a.
Protein Preferred Names Protein Names

alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

  • N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II

  • beta-1,2-N-acetylglucosaminyltransferase II

  • glcNAc-T II

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-159422 S-309309 Inhibitor 98.55% Phase 2

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-U00430 MGAT2-IN-2 Inhibitor / Unkown
HY-181563 MGAT2-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mgat2 NCBI NCBI:4247