Tnfrsf1a - tumor necrosis factor receptor superfamily, member 1a Gene

Also Known as FPF; p55; TNF-R; TNFAR; TNFRI; Tnfr1; p55-R; CD120a; TNF-R1; TNFR60; Tnfr-2; TNF-R-I; TNF-R55; TNFRp55; TNF-alphaR1; TNFalpha-R1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21937

Summary

This gene encodes a member of the TNF Receptor Superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, Apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mice lacking a functional copy of this gene exhibit impaired immune function. [provided by RefSeq, Sep 2016]

Tnfrsf1a Products (1)

mRNA Protein Name
NM_011609.4 NP_035739.2 tumor necrosis factor receptor superfamily member 1A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11374864 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
1647956 MGI
enables tumor necrosis factor receptor activity IDA
IDA: Inferred from direct assay
1647956 MGI
enables tumor necrosis factor receptor activity IGI
IGI: Inferred from genetic interaction
14985352 MGI
enables tumor necrosis factor receptor activity IMP
IMP: Inferred from mutant phenotype
11588035 MGI
enables tumor necrosis factor receptor activity IPI
IPI: Inferred from physical interaction
1645445 MGI
Biological Process GO Annotation Evidence References Source
involved in aortic valve development IGI
IGI: Inferred from genetic interaction
26491108 MGI
acts upstream of or within cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9551933 MGI
acts upstream of or within cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
11588035 MGI
acts upstream of or within defense response IMP
IMP: Inferred from mutant phenotype
8387893 MGI
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
9324362 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
9551933 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
17242187 MGI
involved in negative regulation of cardiac muscle hypertrophy IGI
IGI: Inferred from genetic interaction
26491108 MGI
involved in negative regulation of extracellular matrix constituent secretion IGI
IGI: Inferred from genetic interaction
26491108 MGI
involved in positive regulation of amide metabolic process IGI
IGI: Inferred from genetic interaction
14985352 MGI
involved in positive regulation of apoptotic process involved in morphogenesis IGI
IGI: Inferred from genetic interaction
26491108 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
7525730 MGI
involved in positive regulation of cellular metabolic process IGI
IGI: Inferred from genetic interaction
14985352 MGI
involved in positive regulation of execution phase of apoptosis IGI
IGI: Inferred from genetic interaction
10702415 MGI
involved in positive regulation of execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
10678933 MGI
acts upstream of or within positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
11588035 MGI
involved in positive regulation of lipid metabolic process IGI
IGI: Inferred from genetic interaction
14985352 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11588035 MGI
involved in pulmonary valve development IGI
IGI: Inferred from genetic interaction
26491108 MGI
involved in regulation of membrane lipid metabolic process IGI
IGI: Inferred from genetic interaction
14985352 MGI
acts upstream of or within regulation of tumor necrosis factor-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
25220458 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11588035 MGI
involved in tumor necrosis factor-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
14985352 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
21410936 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
17010968 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
1647956 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 1A

  • TNF receptor alpha chain

  • TNF-RI

  • TNF-alpha-R1

  • TNFR-I

  • p60

  • tumor necrosis factor receptor 1

  • tumor necrosis factor receptor type I

Recombinant Tnfrsf1a Proteins

Cat. No. Product Name Accession Purity
HY-P72443 TNF RI/TNFRSF1A Protein, Mouse P25118 (I22-A212) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73449 TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) P25118/NP_035739.2 (L30-A212) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73450 TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) P25118/NP_035739.2 (L30-A212) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991401 GSK2862277 Antagonist 97.85% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138779 ICCB-19 hydrochloride 99.25% Unkown
HY-N4323 14-Deoxyandrographolide Inhibitor 99.94% Unkown
HY-RS14810 TNFRSF1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174516 Human TNFRSF1A mRNA / Unkown
HY-RS17012 Tnfrsf1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23455 Tnfrsf1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991400 GSK1995057 99.09% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf1a NCBI NCBI:7132