Tpm1 - tropomyosin 1, alpha Gene

Also Known as TM2; Tm3; Tmpa; Tpm-1; alpha-TM; TPM1kappa

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22003

Summary

Enables actin filament binding activity. Involved in cardiac muscle contraction; positive regulation of heart rate by epinephrine; and ventricular cardiac muscle tissue morphogenesis. Acts upstream of or within in utero embryonic development. Located in myofibril. Is expressed in several structures, including central nervous system; gut; heart; limb segment; and musculature. Used to study dilated cardiomyopathy 1Y and hypertrophic cardiomyopathy 3. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Orthologous to human TPM1 (tropomyosin 1). [provided by Alliance of Genome Resources, Apr 2022]

Tpm1 Products (10)

mRNA Protein Name
NM_001164248.1 NP_001157720.1 tropomyosin alpha-1 chain isoform Tpm1.1st
NM_001164249.1 NP_001157721.1 tropomyosin alpha-1 chain isoform Tpm1.2st
NM_001164250.1 NP_001157722.1 tropomyosin alpha-1 chain isoform Tpm1.7cy
NM_001164251.1 NP_001157723.1 tropomyosin alpha-1 chain isoform Tpm1.5cy
NM_001164252.1 NP_001157724.1 tropomyosin alpha-1 chain isoform Tpm1.8cy
NM_001164253.1 NP_001157725.1 tropomyosin alpha-1 chain isoform Tpm1.9cy
NM_001164254.1 NP_001157726.1 tropomyosin alpha-1 chain isoform Tpm1.13
NM_001164255.1 NP_001157727.1 tropomyosin alpha-1 chain isoform Tpm1.10br
NM_001164256.1 NP_001157728.1 tropomyosin alpha-1 chain isoform Tpm1.12br
NM_024427.4 NP_077745.2 tropomyosin alpha-1 chain isoform Tpm1.6cy

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
16765662 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25470062 MGI
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
17556658 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
9400381 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9440710 MGI
involved in positive regulation of heart rate by epinephrine IMP
IMP: Inferred from mutant phenotype
17556658 MGI
involved in ventricular cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
17556658 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16765662 MGI
located in myofibril IDA
IDA: Inferred from direct assay
9440710 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tropomyosin alpha-1 chain

  • alpha-tropomyosin

  • tropomyosin 1 kappa

  • tropomyosin-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14936 TPM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17596 Tpm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24056 Tpm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpm1 NCBI NCBI:7168