Tnfsf10 - tumor necrosis factor (ligand) superfamily, member 10 Gene

Also Known as TL2; Ly81; Trail; APO-2L; Tnlg6a; A330042I21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22035

Summary

Enables TRAIL binding activity and tumor necrosis factor receptor superfamily binding activity. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in extracellular space and plasma membrane. Predicted to be integral component of membrane. Is expressed in central nervous system; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF Superfamily member 10). [provided by Alliance of Genome Resources, Apr 2022]

Tnfsf10 Products (1)

mRNA Protein Name
NM_009425.2 NP_033451.1 tumor necrosis factor ligand superfamily member 10

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables TRAIL binding IDA
IDA: Inferred from direct assay
12466268 MGI
enables tumor necrosis factor receptor superfamily binding IPI
IPI: Inferred from physical interaction
12466268 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
15632112 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 10

  • TNF-related apoptosis-inducing ligand

  • TRAIL/APO2L

  • tumor necrosis factor ligand 6a

Recombinant Tnfsf10 Proteins

Cat. No. Product Name Accession Purity
HY-P7089AF Animal-Free TRAIL/TNFSF10 Protein, Mouse (His) P50592 (P118-N291) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181955 MS1129 / Unkown
HY-RS14818 TNFSF10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17568 Tnfsf10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24028 Tnfsf10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfsf10 NCBI NCBI:8743