Trpc6 - transient receptor potential cation channel, subfamily C, member 6 Gene

Also Known as TRP-6; Trrp6; mtrp6; LLHWJM002; LLHWJM003; LLHWJM004

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22068

Summary

Enables store-operated Calcium Channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Located in plasma membrane and slit diaphragm. Is expressed in several structures, including gut; limb; liver; nervous system; and reproductive system. Used to study focal segmental glomerulosclerosis 2. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6). [provided by Alliance of Genome Resources, Apr 2022]

Trpc6 Products (3)

mRNA Protein Name
NM_001282086.1 NP_001269015.1 short transient receptor potential channel 6 isoform 2
NM_001282087.1 NP_001269016.1 short transient receptor potential channel 6 isoform 3
NM_013838.2 NP_038866.2 short transient receptor potential channel 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
15194687 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15924139 MGI
enables store-operated calcium channel activity IDA
IDA: Inferred from direct assay
8646775 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
9368034 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15924139 MGI
located in slit diaphragm IDA
IDA: Inferred from direct assay
15924139 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

short transient receptor potential channel 6

  • calcium entry channel

  • transient receptor protein 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101795 Larixyl acetate Inhibitor 99.44% Unkown
HY-161766 L687 Activator 99.49% Unkown
HY-179490 AM-0883 Agonist 99.67% Unkown
HY-162090 TRPC antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpc6 NCBI NCBI:7225