OARD1 - O-acyl-ADP-ribose deacylase 1 Gene

Also Known as TARG1; C6orf130; dJ34B21.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 221443

About OARD1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,064,772-41,097,787 (from NCBI)

This gene has 16 transcripts (splice variants) and 240 orthologues. Ubiquitous expression in testis (RPKM 36.5), thyroid (RPKM 20.0) and 25 other tissues.

Summary

The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop. [provided by RefSeq, Jul 2016]

OARD1 Products (13)

mRNA	Protein	Name
NM_001329684.2	NP_001316613.1	ADP-ribose glycohydrolase OARD1 isoform a
NM_001329685.1	NP_001316614.1	ADP-ribose glycohydrolase OARD1 isoform a
NM_001329686.2	NP_001316615.1	ADP-ribose glycohydrolase OARD1 isoform a
NM_001329688.2	NP_001316617.1	ADP-ribose glycohydrolase OARD1 isoform a
NM_001329689.2	NP_001316618.1	ADP-ribose glycohydrolase OARD1 isoform b
NM_001329690.2	NP_001316619.1	ADP-ribose glycohydrolase OARD1 isoform c
NM_001329691.2	NP_001316620.1	ADP-ribose glycohydrolase OARD1 isoform c
NM_001329692.1	NP_001316621.1	ADP-ribose glycohydrolase OARD1 isoform c
NM_001329693.2	NP_001316622.1	ADP-ribose glycohydrolase OARD1 isoform c
NM_001329694.2	NP_001316623.1	ADP-ribose glycohydrolase OARD1 isoform d
NM_001329695.1	NP_001316624.1	ADP-ribose glycohydrolase OARD1 isoform d
NM_001329696.2	NP_001316625.1	ADP-ribose glycohydrolase OARD1 isoform d
NM_145063.4	NP_659500.1	ADP-ribose glycohydrolase OARD1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP-ribosylglutamate hydrolase activity	IDA IDA: Inferred from direct assay	23474714	GOA
enables O-acetyl-ADP-ribose deacetylase activity	IDA IDA: Inferred from direct assay	21849506	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23481255	GOA
enables purine nucleoside binding	IDA IDA: Inferred from direct assay	21849506	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	23481255	GOA
involved in peptidyl-glutamate ADP-deribosylation	IDA IDA: Inferred from direct assay	23474714	GOA
involved in protein de-ADP-ribosylation	IDA IDA: Inferred from direct assay	23474714	GOA
involved in purine nucleoside metabolic process	IDA IDA: Inferred from direct assay	21849506	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleolus	IDA IDA: Inferred from direct assay	29712969	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	29712969	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	23481255	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OARD1 Protein Structure

Macro

0
100
152 a.a.

Protein Preferred Names	Protein Names
ADP-ribose glycohydrolase OARD1	O-acetyl-ADP-ribose deacetylase 1

OARD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OARD1	Q9Y530	TNKS	Homo sapiens	O95271	Y2H Prey Pooling	32296183
Intra	OARD1	Q9Y530	TNKS	Homo sapiens	O95271	Y2H Array	32296183
Intra	OARD1	Q9Y530	PARP10	Homo sapiens	Q53GL7	Enzymatic Study	23481255
Intra	OARD1	Q9Y530	PARP1	Homo sapiens	P09874	Enzymatic Study	23481255
Intra	OARD1	Q9Y530	PARP1	Homo sapiens	P09874	Anti Tag CoIP	23481255
Intra	OARD1	Q9Y530	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	OARD1	Q9Y530	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OARD1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71658	OARD1 Protein, Human (Myc, His)	Q9Y530 (A2-L152)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Arthrogryposis, Renal Dysfunction, And Cholestasis 1	Arc Syndrome ARCS1 Arthrogryposis Renal Dysfunction Cholestasis Syndrome Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome Arcs Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, And Cholestasis Arthrogryposis-Renal Dysfunction-Cholestasis Arthrogryposis - Renal Dysfunction - Cholestasis Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1 Arthrogryposis Renal Dysfunction And Cholestasis 1 Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1 Kidney Failure Renal Insufficiency
Brachydactyly, Type A4	Brachymesophalangy Ii And V Temtamy Type Brachydactyly Brachydactyly Type A4 BDA4 Brachymesophalangy 2 And 5 Brachydactyly Temtamy Type Brachydactyly, Temtamy Type
Eastern Equine Encephalitis	Eee Neuroinvasive Eastern Equine Encephalitis Virus Infection Eastern Equine Encephalomyelitis Encephalomyelitis, Eastern Equine Triple E Eastern Equine Encephalitis Virus Infection Neuroinvasive Eastern Equine Encephalitis Virus Disease Eee - [Eastern Equine Encephalitis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09726	OARD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19223	Oard1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25712	Oard1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OARD1	VGNC	VGNC:32390
Felis catus	OARD1	VGNC	VGNC:102477
Canis familiaris	OARD1	VGNC	VGNC:44085
Mus musculus	OARD1	MGD	MGI:2146818
Rattus norvegicus	OARD1	RGD	RGD:1308299
Macaca mulatta	OARD1	VGNC	VGNC:75444
Others	OARD1	NCBI