PARP10 - poly(ADP-ribose) polymerase family member 10 Gene

Also Known as ARTD10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84875

About PARP10

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,977,158-144,012,764 (from NCBI)

This gene has 23 transcripts (splice variants), 204 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 25.6), lymph node (RPKM 16.2) and 25 other tissues.

Summary

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]

PARP10 Products (6)

mRNA	Protein	Name
NR_134234.2
XM_011517336.4	XP_011515638.1	protein mono-ADP-ribosyltransferase PARP10 isoform X2
XM_047422328.1	XP_047278284.1	protein mono-ADP-ribosyltransferase PARP10 isoform X3
XM_047422327.1	XP_047278283.1	protein mono-ADP-ribosyltransferase PARP10 isoform X1
NM_001317895.2	NP_001304824.1	protein mono-ADP-ribosyltransferase PARP10 isoform 2
NM_032789.5	NP_116178.2	protein mono-ADP-ribosyltransferase PARP10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15674325	GOA
enables K63-linked polyubiquitin modification-dependent protein binding	IMP IMP: Inferred from mutant phenotype	23575687	GOA
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	18851833	GOA
enables NAD+-protein ADP-ribosyltransferase activity	IMP IMP: Inferred from mutant phenotype	24695737	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP IMP: Inferred from mutant phenotype	23473667	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22176891	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromatin organization	IDA IDA: Inferred from direct assay	15674325	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	23575687	GOA
involved in negative regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	15674325	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23575687	GOA
involved in negative regulation of protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	23575687	GOA
involved in protein auto-ADP-ribosylation	IDA IDA: Inferred from direct assay	25043379	GOA
involved in protein auto-ADP-ribosylation	IMP IMP: Inferred from mutant phenotype	23575687	GOA
involved in protein poly-ADP-ribosylation	IDA IDA: Inferred from direct assay	15674325	GOA
involved in protein poly-ADP-ribosylation	IMP IMP: Inferred from mutant phenotype	23473667	GOA
involved in translesion synthesis	IDA IDA: Inferred from direct assay	24695737	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15674325	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15674325	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP10 Protein Structure

PARP

0
200
400
600
800
1025 a.a.

Protein Preferred Names	Protein Names
protein mono-ADP-ribosyltransferase PARP10	ADP-ribosyltransferase diphtheria toxin-like 10 poly [ADP-ribose] polymerase 10

PARP10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PARP10	Q53GL7	OARD1	Homo sapiens	Q9Y530	Enzymatic Study	23481255

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-150207	RBN-3143	Inhibitor	99.29%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136979	RBN012759	Inhibitor	99.33%	Unkown
HY-148566	OUL232	Inhibitor	99.86%	Unkown
HY-123512	OUL35	Inhibitor	99.80%	Unkown
HY-100225	ME0328	Inhibitor	99.64%	Unkown
HY-143398	PARP10/15-IN-1	Inhibitor	95.04%	Unkown
HY-148754	PARP10-IN-3	Inhibitor	98.72%	Unkown
HY-178317	OUL312	Inhibitor	99.20%	Unkown
HY-146502	PARP10/15-IN-3	Inhibitor	99.23%	Unkown
HY-155993	YCH1899	Inhibitor	99.39%	Unkown
HY-148753	PARP10-IN-2	Inhibitor	98.07%	Unkown
HY-121719	TIQ-A	Inhibitor	99.85%	Unkown
HY-146501	PARP10/15-IN-2	Inhibitor	98.92%	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-125217	PARP10-IN-1	Inhibitor	/	Unkown
HY-180926	PARP10-IN-4	Inhibitor	/	Unkown
HY-148710	ARTD10/PARP10-IN-2	Inhibitor	/	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown
HY-172806	PARP14 inhibitor 1	Inhibitor	/	Unkown
HY-148709	ARTD10/PARP10-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PARP10	VGNC	VGNC:108106
Mus musculus	PARP10	MGD	MGI:3712326
Rattus norvegicus	PARP10	RGD	RGD:7744876
Others	PARP10	NCBI