Tubb3 - tubulin, beta 3 class III Gene

Also Known as M(beta)3; M(beta)6; 3200002H15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22152

Summary

Enables netrin receptor binding activity. Involved in axon guidance and netrin-activated signaling pathway. Located in several cellular components, including filopodium; growth cone; and lamellipodium. Is expressed in several structures, including alimentary system; cardiovascular system; embryo ectoderm; nervous system; and sensory organ. Used to study congenital fibrosis of the extraocular muscles. Human ortholog(s) of this gene implicated in complex cortical dysplasia with Other brain malformations 1 and congenital fibrosis of the extraocular muscles 3A. Orthologous to human TUBB3 (tubulin beta 3 class III). [provided by Alliance of Genome Resources, Apr 2022]

Tubb3 Products (1)

mRNA Protein Name
NM_023279.3 NP_075768.1 tubulin beta-3 chain

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables netrin receptor binding IPI
IPI: Inferred from physical interaction
28483977 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17389232 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
20074521 MGI
involved in netrin-activated signaling pathway IMP
IMP: Inferred from mutant phenotype
28483977 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in axon IDA
IDA: Inferred from direct assay
15255972 MGI
located in cell periphery IDA
IDA: Inferred from direct assay
24378336 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19036983 MGI
located in dendrite IDA
IDA: Inferred from direct assay
24464040 MGI
located in filopodium IDA
IDA: Inferred from direct assay
28483977 MGI
located in growth cone IDA
IDA: Inferred from direct assay
28483977 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
16892058 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
28483977 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
15003631 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
23284756 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tubulin beta-3 chain

  • betaIII-tubulin

Tubb3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Tubb3 Q9ERD7 Capzb Mus musculus P47757
Anti Bait CoIP
19806181
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-158208 PMMB276 Inhibitor 99.81% Unkown
HY-158208A (1S)-PMMB276 Control / Unkown
HY-RS15254 TUBB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19491 Tubb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25985 Tubb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tubb3 NCBI NCBI:10381