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FCN1 - ficolin 1 Gene

Also Known as FCNM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2219

About FCN1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:134,903,232-134,917,912 (from NCBI)

This gene has 1 transcript (splice variant), 114 orthologues and 25 paralogues. Biased expression in bone marrow (RPKM 318.5), appendix (RPKM 117.5) and 3 other tissues.

Summary

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in Other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]

FCN1 Products (1)

mRNA	Protein	Name
NM_002003.5	NP_001994.2	ficolin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	21037097	GOA
enables pattern recognition receptor activity	IMP IMP: Inferred from mutant phenotype	21037097	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17581635	GOA
enables sialic acid binding	IDA IDA: Inferred from direct assay	20400674	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	21037097	GOA
involved in cell surface pattern recognition receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21037097	GOA
involved in complement activation, lectin pathway	IDA IDA: Inferred from direct assay	16116205	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	22851708	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	21037097	GOA
involved in positive regulation of opsonization	IDA IDA: Inferred from direct assay	16116205	GOA
involved in protein localization to cell surface	IDA IDA: Inferred from direct assay	20400674	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	16116205	GOA
involved in recognition of apoptotic cell	IDA IDA: Inferred from direct assay	15804047	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21037097	GOA
part of serine-type endopeptidase complex	IDA IDA: Inferred from direct assay	16116205	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCN1 Protein Structure

Collagen

Fibrinogen_C

0
100
200
300
326 a.a.

Protein Preferred Names	Protein Names
ficolin-1	M-ficolin

FCN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FCN1	O00602	CRP	Homo sapiens	P02741	ELISA	21037097
Intra	FCN1	O00602	CRP	Homo sapiens	P02741	H1-H2 MS	21037097
Intra	FCN1	O00602	CRP	Homo sapiens	P02741	PLA	21037097
Cross	FCN1	O00602	CRP-1	Carcinoscorpius rotundicauda	Q2TS39	Saturation Binding	17581635
Cross	FCN1	O00602	CRP-1	Carcinoscorpius rotundicauda	Q2TS39	Pull Down	17581635

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76930	Ficolin-1 Protein, Human (HEK293, His)	NP_001994.2 (A30-A326)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Rheumatic Fever	Acute Rheumatic Fever Rhf - Rheumatic Fever Inflammatory Rheumatism Active Rheumatic Fever Nos Acute Active Rheumatic Fever Subacute Active Rheumatic Fever Subacute Rheumatic Fever Active Rheumatic Fever With Unspecified Type Of Heart Involvement Acute Rheumatic Heart Disease Active Rheumatic Heart Disease Acute Organic Rhd - [Rheumatic Heart Disease] Acute Rhd - [Rheumatic Heart Disease]
Pulmonary Aspergilloma
3mc Syndrome 2	3MC2 Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia Oculo-Skeletal-Abdominal Syndrome Osa Syndrome Carnevale Syndrome Carnevale Syndrome, Formerly Carnevale Krajewska Fischetto Syndrome 3mc Syndrome, Type 2
3mc Syndrome 1	Oculopalatoskeletal Syndrome 3MC1 Craniosynostosis With Lid Anomalies Michels Syndrome, Formerly Michels Syndrome 3mc Syndrome, Type 1
3mc Syndrome	Craniofacial-Ulnar-Renal Syndrome Malpuech Facial Clefting Syndrome Oculopalatoskeletal Syndrome Carnevale Syndrome Michels Syndrome Malpuech-Michels-Mingarelli-Carnevale Syndrome Carnevale-Krajewska-Fischetto Syndrome Craniosynostosis With Lid Anomalies Malpuech Syndrome Mingarelli Syndrome Oculo-Skeletal-Abdominal Syndrome Osa Syndrome Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia Ptosis-Strabismus-Rectus Abdominis Diastasis
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04839	FCN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FCN1	MGD	MGI:1341158
Rattus norvegicus	FCN1	RGD	RGD:621222
Others	FCN1	NCBI