ZNRF2 - zinc and ring finger 2 Gene

Also Known as RNF202

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 223082

About ZNRF2

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,284,597-30,367,689 (from NCBI)

This gene has 2 transcripts (splice variants), 198 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.0), colon (RPKM 12.4) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase activity. Predicted to be involved in protein ubiquitination. Located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

ZNRF2 Products (1)

mRNA Protein Name
NM_147128.4 NP_667339.1 E3 ubiquitin-protein ligase ZNRF2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
22797923 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of autophagosome-lysosome fusion IGI
IGI: Inferred from genetic interaction
38360932 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22797923 GOA
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
22797923 GOA
is active in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
22797923 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
22797923 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
22797923 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNRF2 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (197 - 237)

  • 0
  • 100
  • 200
  • 242 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase ZNRF2

  • RING finger protein 202

ZNRF2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83446 ZNRF2 Antibody (YA3191) WB, IHC-P Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16184 ZNRF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZNRF2 MGD MGI:1196246
Bos taurus ZNRF2 VGNC VGNC:37364
Felis catus ZNRF2 VGNC VGNC:80769
Rattus norvegicus ZNRF2 RGD RGD:1306645
Macaca mulatta ZNRF2 VGNC VGNC:79353
Others ZNRF2 NCBI