ZNRF2 Antibody (YA3191)
(Synonyms: E3 ubiquitin-protein ligase ZNRF2; ZNRF2; Zinc/RING finger protein 2; RNF202; Protein Ells2)ZNRF2 Antibody (YA3191) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ZNRF2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
ZNRF2 Antibody (YA3191) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ZNRF2.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 24 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 24 kDa
Entrez Gene: 223082 Human ; 387524 Mouse ; 362367 Rat
SwissProt: Q8NHG8 Human ; Q71FD5 Mouse ;
OMIM: 612061 Human
A synthesized peptide derived from human ZNRF2 aa150-242.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ZNRF2 is an E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism[1][2].
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Subcellular Localization
Endosome membrane; Peripheral membrane protein; Lysosome membrane; Peripheral membrane protein; Presynaptic cell membrane; Peripheral membrane protein; Cytoplasm
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Expression
Tissue_specificity:Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney -
Subunit
Interacts with UBE2N (PubMed:16215985). Interacts with ZNRF1 (PubMed:22797923). Interacts (when phosphorylated) with YWHAE (PubMed:22797923)
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SwissProt ID
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Synonyms
E3 ubiquitin-protein ligase ZNRF2; ZNRF2; Zinc/RING finger protein 2; RNF202; Protein Ells2
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Research Field
Cell Biology
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