Vldlr - very low density lipoprotein receptor Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22359

Summary

Enables reelin receptor activity. Involved in dendrite morphogenesis; positive regulation of dendrite development; and reelin-mediated signaling pathway. Acts upstream of or within positive regulation of protein kinase activity and ventral spinal cord development. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Used to study age related macular degeneration 1. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, mental retardation and dysequlibrium syndrome; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2022]

Vldlr Products (4)

mRNA Protein Name
NM_001161420.1 NP_001154892.1 very low-density lipoprotein receptor isoform b precursor
NM_001347441.1 NP_001334370.1 very low-density lipoprotein receptor isoform c precursor
NM_001412816.1 NP_001399745.1 very low-density lipoprotein receptor isoform c precursor
NM_013703.2 NP_038731.2 very low-density lipoprotein receptor isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15249135 MGI
enables reelin receptor activity IDA
IDA: Inferred from direct assay
10571241 MGI
enables reelin receptor activity IGI
IGI: Inferred from genetic interaction
18778775 MGI
enables reelin receptor activity IMP
IMP: Inferred from mutant phenotype
18778775 MGI
Biological Process GO Annotation Evidence References Source
involved in dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
18778775 MGI
involved in positive regulation of dendrite development IGI
IGI: Inferred from genetic interaction
18778775 MGI
acts upstream of or within positive regulation of protein kinase activity IGI
IGI: Inferred from genetic interaction
12526740 MGI
involved in reelin-mediated signaling pathway IDA
IDA: Inferred from direct assay
10571241 MGI
involved in reelin-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
18778775 MGI
involved in regulation of synapse assembly IDA
IDA: Inferred from direct assay
25644714 MGI
involved in regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
25644714 MGI
involved in ventral spinal cord development IEP
IEP: Inferred from expression pattern
20711475 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15950758 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25644714 MGI
is active in synapse IDA
IDA: Inferred from direct assay
25644714 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

very low-density lipoprotein receptor

  • VLDL receptor

  • VLDL-R

Recombinant Vldlr Proteins

Cat. No. Product Name Accession Purity
HY-P78049 VLDLR Protein, Mouse (HEK293, His) P98156 (G28-S797) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15661 VLDLR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18002 Vldlr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24474 Vldlr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990143 Anti-Mouse/Rat/Bovine VLDL-R Antibody (IgG-6A6) Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vldlr NCBI NCBI:7436