Traf7 - TNF receptor-associated factor 7 Gene

Also Known as RFWD1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 224619

Summary

Predicted to enable ubiquitin-protein transferase activity. Acts upstream of or within several processes, including cellular response to interleukin-6; negative regulation of transcription by RNA polymerase II; and positive regulation of protein sumoylation. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in genitourinary system and pancreas epithelium. Orthologous to human TRAF7 (TNF Receptor associated factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Traf7 Products (3)

mRNA Protein Name
NM_001172113.1 NP_001165584.1 E3 ubiquitin-protein ligase TRAF7 isoform 1
NM_001172114.1 NP_001165585.1 E3 ubiquitin-protein ligase TRAF7 isoform 2
NM_153792.2 NP_722487.2 E3 ubiquitin-protein ligase TRAF7 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16162816 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to interleukin-6 IDA
IDA: Inferred from direct assay
16162816 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16162816 MGI
acts upstream of or within positive regulation of protein sumoylation IDA
IDA: Inferred from direct assay
16162816 MGI
acts upstream of or within regulation of protein localization IDA
IDA: Inferred from direct assay
16162816 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
16162816 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16162816 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16162816 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRAF7

  • RING-type E3 ubiquitin transferase TRAF7

  • ring finger and WD repeat domain 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14976 TRAF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20502 Traf7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27010 Traf7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Traf7 NCBI NCBI:84231