Onecut2 - one cut domain, family member 2 Gene

Also Known as Oc2; OC-2; C730009D12

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225631

Summary

Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including liver development; negative regulation of transforming growth factor beta receptor signaling pathway; and peripheral nervous system neuron development. Predicted to be located in actin Cytoskeleton and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future brain; genitourinary system; gut; and retina. Orthologous to human ONECUT2 (one cut homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Onecut2 Products (1)

mRNA Protein Name
NM_194268.3 NP_919244.2 one cut domain family member 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17400205 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11944891 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anatomical structure morphogenesis IMP
IMP: Inferred from mutant phenotype
16103213 MGI
acts upstream of or within cell fate commitment IGI
IGI: Inferred from genetic interaction
16103213 MGI
acts upstream of cell migration IGI
IGI: Inferred from genetic interaction
17936262 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
16472605 MGI
acts upstream of or within endocrine pancreas development IGI
IGI: Inferred from genetic interaction
17400205 MGI
acts upstream of or within epithelial cell development IMP
IMP: Inferred from mutant phenotype
16472605 MGI
acts upstream of or within liver development IGI
IGI: Inferred from genetic interaction
17936262 MGI
acts upstream of mesenchymal stem cell migration IGI
IGI: Inferred from genetic interaction
17936262 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16103213 MGI
acts upstream of or within pancreas development IGI
IGI: Inferred from genetic interaction
17400205 MGI
acts upstream of or within peripheral nervous system neuron development IMP
IMP: Inferred from mutant phenotype
17698011 MGI
acts upstream of or within positive regulation of mesenchymal stem cell migration IGI
IGI: Inferred from genetic interaction
17936262 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17400205 MGI
acts upstream of or within regulation of cell-matrix adhesion IGI
IGI: Inferred from genetic interaction
17936262 MGI
acts upstream of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16103213 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

one cut domain family member 2

  • one cut homeobox 2

  • transcription factor ONECUT-2

  • transcription factor ONECUT2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122611A CSRM617 hydrochloride 99.97% Unkown
HY-122611 CSRM617 / Unkown
HY-RS09786 ONECUT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19546 Onecut2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26042 Onecut2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Onecut2 NCBI NCBI:9480