Kmt5b - lysine methyltransferase 5B Gene

Also Known as Suv420h1; Suv4-20h1; C630029K18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225888

Summary

Enables S-adenosyl-L-methionine binding activity and Histone Methyltransferase activity (H4-K20 specific). Involved in positive regulation of isotype switching. Acts upstream of or within histone methylation. Located in condensed chromosome, centromeric region. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 51. Orthologous to human KMT5B (lysine methyltransferase 5B). [provided by Alliance of Genome Resources, Apr 2022]

Kmt5b Products (10)

mRNA Protein Name
NM_001167884.1 NP_001161356.1 histone-lysine N-methyltransferase KMT5B isoform d
NM_001167885.1 NP_001161357.1 histone-lysine N-methyltransferase KMT5B isoform a
NM_001167886.1 NP_001161358.1 histone-lysine N-methyltransferase KMT5B isoform b
NM_001167887.1 NP_001161359.1 histone-lysine N-methyltransferase KMT5B isoform a
NM_001167888.1 NP_001161360.1 histone-lysine N-methyltransferase KMT5B isoform d
NM_001167889.2 NP_001161361.1 histone-lysine N-methyltransferase KMT5B isoform c
NM_001379678.1 NP_001366607.1 histone-lysine N-methyltransferase KMT5B isoform a
NM_001379679.1 NP_001366608.1 histone-lysine N-methyltransferase KMT5B isoform b
NM_001379680.1 NP_001366609.1 histone-lysine N-methyltransferase KMT5B isoform e
NM_144871.4 NP_659120.3 histone-lysine N-methyltransferase KMT5B isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
24049080 MGI
enables histone H4K20 methyltransferase activity IDA
IDA: Inferred from direct assay
15145825 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of isotype switching IMP
IMP: Inferred from mutant phenotype
28114273 MGI
Cellular Component GO Annotation Evidence References Source
located in condensed chromosome, centromeric region IDA
IDA: Inferred from direct assay
15145825 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase KMT5B

  • [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B

  • [histone H4]-lysine20 N-methyltransferase KMT5B

  • histone-lysine N-methyltransferase SUV420H1

  • lysine-specific methyltransferase 5B

  • su(var)4-20 homolog 1

  • suppressor of variegation 4-20 homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07407 KMT5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21619 Kmt5b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28137 Kmt5b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kmt5b NCBI NCBI:51111