Twnk - twinkle mtDNA helicase Gene

Also Known as PEO; Peo1; Twinl; D19Ertd626e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 226153

Summary

Enables DNA helicase activity. Involved in mitochondrial DNA replication. Acts upstream of or within DNA unwinding involved in DNA replication. Located in mitochondrion. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Perrault syndrome; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3; chronic progressive external ophthalmoplegia; and mitochondrial DNA depletion syndrome 7. Orthologous to human TWNK (twinkle mtDNA helicase). [provided by Alliance of Genome Resources, Apr 2022]

Twnk Products (3)

mRNA Protein Name
NM_001348254.1 NP_001335183.1 twinkle mtDNA helicase isoform 3
NM_001348259.1 NP_001335188.1 twinkle mtDNA helicase isoform 2
NM_153796.4 NP_722491.2 twinkle mtDNA helicase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA helicase activity IDA
IDA: Inferred from direct assay
11431692 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA unwinding involved in DNA replication IDA
IDA: Inferred from direct assay
11431692 MGI
involved in mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
18971204 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
11431692 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

twinkle mtDNA helicase

  • T7 gp4-like protein with intramitochondrial nucleoid localization

  • progressive external ophthalmoplegia 1 protein homolog

  • putative T7-like mitochodrial DNA helicase twinky

  • twinkle protein, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15283 TWNK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20832 Twnk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27346 Twnk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Twnk NCBI NCBI:56652