ALDOC - aldolase, fructose-bisphosphate C Gene

Also Known as ALDC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 230

About ALDOC

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,573,120-28,576,895 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 2 paralogues. Biased expression in brain (RPKM 270.0), fat (RPKM 67.7) and 5 other tissues.

Summary

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

ALDOC Products (1)

mRNA Protein Name
NM_005165.3 NP_005156.1 fructose-bisphosphate aldolase C

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytoskeletal protein binding IDA
IDA: Inferred from direct assay
9244396 GOA
enables fructose-bisphosphate aldolase activity IDA
IDA: Inferred from direct assay
9244396 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11399750 GOA
Biological Process GO Annotation Evidence References Source
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
21492153 GOA
involved in fructose 1,6-bisphosphate metabolic process IDA
IDA: Inferred from direct assay
9244396 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDOC Protein Structure

Glycolytic

Glycolytic: Fructose-bisphosphate aldolase class-I (15 - 364)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

fructose-bisphosphate aldolase C

  • aldolase 3

ALDOC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ALDOC P09972 ALDOA Homo sapiens P04075-2
Y2H Prey Pooling
25416956
Intra
ALDOC P09972 ANKS1A Homo sapiens Q49AR9
Validated Y2H
32296183
Intra
ALDOC P09972 ALDOA Homo sapiens P04075
Anti Tag CoIP
33961781
Intra
ALDOC P09972 ALDOA Homo sapiens P04075
Anti Tag CoIP
28514442
Intra
ALDOC P09972 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALDOC Proteins

Cat. No. Product Name Accession Purity
HY-P7478 Aldolase C Protein, Human (HEK293, His) P09972 (P2-Y364) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00585 ALDOC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18160 Aldoc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24634 Aldoc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ALDOC VGNC VGNC:59741
Macaca mulatta ALDOC VGNC VGNC:69792
Bos taurus ALDOC VGNC VGNC:25823
Mus musculus ALDOC MGD MGI:101863
Rattus norvegicus ALDOC RGD RGD:2091
Canis familiaris ALDOC VGNC VGNC:37793
Others ALDOC NCBI