Vgll4 - vestigial like family member 4 Gene

Also Known as VGL-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 232334

Summary

Predicted to enable transcription coactivator binding activity. Involved in several processes, including negative regulation of cardiac muscle cell proliferation; negative regulation of hippo signaling; and positive regulation of cellular protein catabolic process. Located in nucleus. Is expressed in lung; submandibular gland primordium; tooth; and vibrissa. Orthologous to human VGLL4 (vestigial like family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Vgll4 Products (6)

mRNA Protein Name
NM_001356371.2 NP_001343300.1 transcription cofactor vestigial-like protein 4 isoform 2
NM_001411599.1 NP_001398528.1 transcription cofactor vestigial-like protein 4 isoform 2
NM_001411600.1 NP_001398529.1 transcription cofactor vestigial-like protein 4 isoform 3 precursor
NM_001411601.1 NP_001398530.1 transcription cofactor vestigial-like protein 4 isoform 4
NM_001411602.1 NP_001398531.1 transcription cofactor vestigial-like protein 4 isoform 5
NM_177683.4 NP_808351.1 transcription cofactor vestigial-like protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15140898 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15140898 MGI
involved in negative regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
27720608 MGI
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
27720608 MGI
involved in positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
27720608 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15140898 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription cofactor vestigial-like protein 4

  • vestigial like 4

Vgll4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Vgll4 Q80V24 Tead4 Mus musculus Q62296
GMS
24525233
Intra
Vgll4 Q80V24 Tead4 Mus musculus Q62296
DLS
24525233
Intra
Vgll4 Q80V24 Tead4 Mus musculus Q62296
X-Ray Diffraction
24525233
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137479 TEAD-IN-1 Inhibitor 99.43% Unkown
HY-RS15647 VGLL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22913 Vgll4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29427 Vgll4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vgll4 NCBI NCBI:9686