Wnk1 - WNK lysine deficient protein kinase 1 Gene

Enables protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; lymphocyte migration into lymph node; and peptidyl-serine phosphorylation. Acts upstream of or within several processes, including negative regulation of GTPase activity; negative regulation of pancreatic juice secretion; and positive regulation of systemic arterial blood pressure. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]