OTUD3 - OTU deubiquitinase 3 Gene

Also Known as DUBA4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23252

About OTUD3

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,882,395-19,912,945 (from NCBI)

This gene has 3 transcripts (splice variants), 211 orthologues and 5 paralogues. Broad expression in testis (RPKM 8.1), endometrium (RPKM 3.2) and 23 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Acts upstream of or within negative regulation of protein kinase B signaling; protein deubiquitination; and protein stabilization. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OTUD3 Products (1)

mRNA Protein Name
NM_015207.2 NP_056022.1 OTU domain-containing protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
23827681 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
26280536 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26280536 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
35675826 GOA
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
26280536 GOA
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
26280536 GOA
acts upstream of or within protein K11-linked deubiquitination IDA
IDA: Inferred from direct assay
26280536 GOA
involved in protein K11-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
acts upstream of or within protein K27-linked deubiquitination IDA
IDA: Inferred from direct assay
26280536 GOA
acts upstream of or within protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
26280536 GOA
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
35675826 GOA
acts upstream of or within protein K6-linked deubiquitination IDA
IDA: Inferred from direct assay
26280536 GOA
involved in protein K6-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
32011234 GOA
acts upstream of or within protein stabilization IDA
IDA: Inferred from direct assay
26280536 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
35675826 GOA
acts upstream of or within protein stabilization IMP
IMP: Inferred from mutant phenotype
26280536 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26280536 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
35675826 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUD3 Protein Structure

OTU

OTU: OTU-like cysteine protease (71 - 182)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

OTU domain-containing protein 3

  • OTU domain containing 3

OTUD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OTUD3 Q5T2D3 PTEN Homo sapiens P60484-1
Anti Tag CoIP
26280536
Intra
OTUD3 Q5T2D3 PTEN Homo sapiens P60484-1
Pull Down
26280536
Intra
OTUD3 Q5T2D3 HSD17B14 Homo sapiens Q9BPX1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09872 OTUD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19728 Otud3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26224 Otud3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus OTUD3 RGD RGD:1560468
Macaca mulatta OTUD3 VGNC VGNC:100022
Felis catus OTUD3 VGNC VGNC:80296
Mus musculus OTUD3 MGD MGI:1920412
Canis familiaris OTUD3 VGNC VGNC:44185
Bos taurus OTUD3 VGNC VGNC:32494
Others OTUD3 NCBI