Kmt5c - lysine methyltransferase 5C Gene

Also Known as Suv420h2; Suv4-20h2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 232811

Summary

Enables histone binding activity and Histone Methyltransferase activity (H4-K20 specific). Involved in positive regulation of isotype switching. Acts upstream of or within histone H4-K20 trimethylation. Located in condensed chromosome, centromeric region. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; sensory organ; and urinary system. Orthologous to human KMT5C (lysine methyltransferase 5C). [provided by Alliance of Genome Resources, Apr 2022]

Kmt5c Products (3)

mRNA Protein Name
NM_001115018.1 NP_001108490.1 histone-lysine N-methyltransferase KMT5C
NM_001358044.1 NP_001344973.1 histone-lysine N-methyltransferase KMT5C
NM_146177.2 NP_666289.2 histone-lysine N-methyltransferase KMT5C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H4K20 methyltransferase activity IDA
IDA: Inferred from direct assay
15145825 MGI
enables histone binding IDA
IDA: Inferred from direct assay
24049080 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of isotype switching IMP
IMP: Inferred from mutant phenotype
28114273 MGI
Cellular Component GO Annotation Evidence References Source
located in condensed chromosome, centromeric region IDA
IDA: Inferred from direct assay
15145825 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase KMT5C

  • [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B

  • [histone H4]-lysine20 N-methyltransferase KMT5B

  • histone-lysine N-methyltransferase SUV420H2

  • lysine-specific methyltransferase 5C

  • su(var)4-20 homolog 2

  • suppressor of variegation 4-20 homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19213 Kmt5c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07408 KMT5C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25702 Kmt5c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kmt5c NCBI NCBI:84787