KMT5C - lysine methyltransferase 5C Gene

Also Known as SUV420H2; Suv4-20h2

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 84787

About KMT5C

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,339,876-55,348,121 (from NCBI)

This gene has 12 transcripts (splice variants), 172 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 1.9), placenta (RPKM 1.5) and 25 other tissues.

Summary

SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]

KMT5C Products (1)

mRNA Protein Name
NM_032701.4 NP_116090.2 histone-lysine N-methyltransferase KMT5C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
24049080 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
28114273 GOA
enables histone H4K20 methyltransferase activity IDA
IDA: Inferred from direct assay
24049080 GOA
enables histone H4K20 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
28114273 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19486527 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in DNA repair IMP
IMP: Inferred from mutant phenotype
28114273 GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
28114273 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in heterochromatin IDA
IDA: Inferred from direct assay
19486527 GOA
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
19486527 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KMT5C Protein Structure

SET

SET: SET domain (156 - 218)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase KMT5C

  • [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B

KMT5C Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
KMT5C Q86Y97 CBX3 Homo sapiens Q13185
Pull Down
19486527
Intra
KMT5C Q86Y97 CBX3 Homo sapiens Q13185
TAP
24981860
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KMT5C Proteins

製品番号 製品名 アクセッション番号 純度
HY-P77218 SUV420H2 Protein, Human (His) Q86Y97-1 (G2-L280) ≥ 80%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Hyperoxaluria, Primary, Type I

  • Primary Hyperoxaluria Type 1

  • HP1

  • Glycolic Aciduria

  • Alanine-Glyoxylate Aminotransferase Deficiency

  • Hepatic Agt Deficiency

  • Oxalosis I

  • Primary Hyperoxaluria, Type I

  • Serine:Pyruvate Aminotransferase Deficiency

  • Hyperoxaluria, Primary, Type 1

  • Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

  • Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

  • Serine Pyruvate Aminotransferase Deficiency

  • Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

  • Oxalosis 1

  • Hyperoxaluria Primary 1

  • Hyperoxaluria Primary Type I

  • Ph1

  • Primary Hyperoxaluria Type I

  • Oxalosis Type 1

  • 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

  • Hyperoxaluria

  • Hyperoxaluria, Primary

  • Oxalosis

  • Primary Oxalosis

  • Congenital Oxaluria

  • D-Glycerate Dehydrogenase Deficiency

  • Glyceric Aciduria

  • Glycolic Aciduria

  • Hepatic Agt Deficiency

  • Oxaluria, Primary

  • Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

  • Primary Oxaluria

  • Hyperoxaluria Primary

  • Primary Hyperoxaluria Type 2

  • Primary Hyperoxaluria, Type I
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS19213 Kmt5c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07408 KMT5C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25702 Kmt5c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris KMT5C VGNC VGNC:42495
Mus musculus KMT5C MGD MGI:2385262
Bos taurus KMT5C VGNC VGNC:30695
Felis catus KMT5C VGNC VGNC:63164
Rattus norvegicus KMT5C RGD RGD:1305226
Others KMT5C NCBI