FMOD - fibromodulin Gene

Homo sapiens

Also known as FM; SLRR2E

Gene ID: 2331 | Gene type: protein coding

About FMOD

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,340,628-203,351,122 (from NCBI)

This gene has 4 transcripts (splice variants), 254 orthologues and 10 paralogues. Broad expression in gall bladder (RPKM 78.8), fat (RPKM 77.4) and 22 other tissues.

Summary

Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

FMOD Products(1)

mRNA	Protein	Name
NM_002023.5	NP_002014.2	fibromodulin precursor

FMOD Protein Structure

LRRNT

LRR_8

LRR_6

0
100
200
300
376 a.a.

Protein Preferred Names

Protein Names

fibromodulin

KSPG fibromodulin

Recombinant FMOD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75186	Fibromodulin Protein, Human (HEK293, hFc)	Q06828 (M1-I376)	≥95%

Related Diseases

Diseases

Alias

Pseudoachondroplasia

PSACH	Pseudoachondroplastic Dysplasia
Pseudoachondroplastic Spondyloepiphyseal Dysplasia Syndrome	Spondyloepiphyseal Dysplasia, Pseudoachondroplastic
Pseudoachondroplastic Spondyloepiphyseal Dysplasia	Spondyloepiphyseal Dysplasia Pseudoachondroplastic

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Refractive Error

Refractive Errors

Craniometaphyseal Dysplasia, Autosomal Dominant

Craniometaphyseal Dysplasia	CMDD
Cmdj	Cmd
Autosomal Dominant Craniometaphyseal Dysplasia	Craniometaphyseal Dysplasia, Jackson Type
Craniometaphyseal Dysplasia Jackson Type	Autosomal Recessive Craniometaphyseal Dysplasia
Cmdr	Dysplasia, Craniometaphyseal, Autosomal Dominant
Craniometaphyseal Dysplasia, Autosomal Recessive Type

Cornea Plana

Flat Cornea

Calcific Tendinitis

Calcific Tendinitis Nos

Corneal Dystrophy, Posterior Amorphous

Posterior Amorphous Corneal Dystrophy	PACD
Chromosome 12q21.33 Deletion Syndrome	Posterior Amorphous Stromal Dystrophy

Macular Dystrophy, Corneal

Macular Corneal Dystrophy	MCD
Corneal Dystrophy, Macular Type	Groenouw Type Ii Corneal Dystrophy
Fehr Corneal Dystrophy	Macular Dystrophy, Corneal Type 1
Mcdc1	Macular Corneal Dystrophy Type Ii
Macular Corneal Dystrophy, Type Ii	Macular Corneal Dystrophy, Type I
Mcdc1, Formerly	Macular Dystrophy, Corneal, 1
Macular Corneal Dystrophy Type 1	Corneal Dystrophy Groenouw Type Ii
Corneal Dystrophy Macular Type	Macular Corneal Dystrophy Type I
Dystrophy, Macular, Corneal

Hypochondrogenesis

Achondrogenesis Type Ii/Hypochondrogenesis

Kniest Dysplasia

Kniest Syndrome	Metatropic Dwarfism, Type Ii
Kniest Chondrodystrophy	Metatropic Dysplasia Type Ii
Swiss Cheese Cartilage Dysplasia	KD
Ks	Metatropic Dwarfism Type Ii
Dysplasia, Kniest

Discitis

Stromal Dystrophy

Fibrochondrogenesis

Fbcg1	Fbcg2
Fibrochondrogenesis-1	Fibrochondrogenesis-2
Fibrochondrogenesis 1	Fibrochondrogenesis 2

Tendinitis

Tendinopathy

Marshall Syndrome

MRSHS	Deafness, Myopia, Cataract, Saddle Nose-Marshall Type
Periodic Fever, Aphthous Stomatitis, Pharyngitis And Adenitis	Pfapa Syndrome
Pfapa	Marshall Syndrome With Periodic Fever
Periodic Fever-Aphtous Stomatitis-Pharyngitis-Adenopathy Syndrome

Corneal Dystrophy, Congenital Stromal

Congenital Stromal Corneal Dystrophy	CSCD
Congenital Hereditary Stromal Dystrophy	Congenital Hereditary Stromal Dystrophy Of The Cornea
Congenital Stromal Dystrophy Of The Cornea	Dacs
Decorin-Associated Congenital Stromal Corneal Dystrophy	Dystrophia Corneae Parenchymatosa Congenita
Witschel Dystrophy	Dystrophy, Corneal, Stromal, Congenital

Ehlers-Danlos Syndrome

Eds	Cutis Hyperelastica
Elastic Skin	Ehlers-Danlos Syndromes
Ed Syndrome	Ehlers Danlos Syndrome
Ehlers Danlos Disease	Eds - [Ehlers-Danlos Syndrome]

Stickler Syndrome

Arthroophthalmopathy	Hereditary Arthro-Ophthalmo-Dystrophy
Hereditary Arthro-Ophthalmopathy	Stickler Dysplasia
Hereditary Progressive Arthroophthalmopathy	Stickler Syndrome, Type 1

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05010	FMOD Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FMOD	VGNC	VGNC:29054
Canis familiaris	FMOD	VGNC	VGNC:40921
Mus musculus	FMOD	MGD	MGI:1328364
Rattus norvegicus	FMOD	RGD	RGD:619769
Felis catus	FMOD	VGNC	VGNC:62312
Macaca mulatta	FMOD	VGNC	VGNC:72686
Others	FMOD	NCBI