NCAPD3 - non-SMC condensin II complex subunit D3 Gene

Also Known as CAPD3; hcp-6; CAP-D3; MCPH22; hHCP-6; hCAP-D3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23310

About NCAPD3

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:134,150,113-134,225,461 (from NCBI)

This gene has 29 transcripts (splice variants), 193 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in prostate (RPKM 42.0), bone marrow (RPKM 7.1) and 20 other tissues.

Summary

Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]

NCAPD3 Products (5)

mRNA	Protein	Name
NM_001372065.1	NP_001358994.1	condensin-2 complex subunit D3 isoform 3
NM_001372068.1	NP_001358997.1	condensin-2 complex subunit D3 isoform 2
NM_001372069.1	NP_001358998.1	condensin-2 complex subunit D3 isoform 4
NM_001372070.1	NP_001358999.1	condensin-2 complex subunit D3 isoform 4
NM_015261.3	NP_056076.1	condensin-2 complex subunit D3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	20622854	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17268547	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic chromosome condensation	IDA IDA: Inferred from direct assay	14532007	GOA
involved in mitotic chromosome condensation	IMP IMP: Inferred from mutant phenotype	27737959	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of condensin complex	IDA IDA: Inferred from direct assay	14532007	GOA
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	20551165	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCAPD3 Protein Structure

Cohesin_HEAT

Cnd1

0
300
600
900
1200
1498 a.a.

Protein Preferred Names	Protein Names
condensin-2 complex subunit D3

NCAPD3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NCAPD3	P42695	NCAPH2	Homo sapiens	Q6IBW4	Anti Tag CoIP	26496610
Intra	NCAPD3	P42695	NCAPH2	Homo sapiens	Q6IBW4	Anti Bait CoIP	17268547
Intra	NCAPD3	P42695	GAPDH	Homo sapiens	P04406	Anti Bait CoIP	29028794
Intra	NCAPD3	P42695	EPRS1	Homo sapiens	P07814	Anti Bait CoIP	29028794

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Microcephaly 22, Primary, Autosomal Recessive	MCPH22
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Microcephaly 19, Primary, Autosomal Recessive	MCPH19 Primary Autosomal Recessive Microcephaly 19 Microcephaly, Type 19, Primary, Autosomal Recessive
Glanders	Farcy Pipes Infection Due To Pseudomonas Mallei Burkholderia Mallei Burkholderia Mallei Infection Equina Equine Glanders Farcy Farcy Buds Farcy Cords Infection Due To Actinobacillus Mallei Infection Due To Malleomyces Mallei Maliasmus Malleus Farce Actinobacillosis Actinobacillus Infection
Currarino Syndrome	Currarino Triad Partial Sacral Agenesis With Intact First Sacral Vertebra, Presacral Mass And Anorectal Malformation CURRAS
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09067	NCAPD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NCAPD3	MGD	MGI:2142989
Macaca mulatta	NCAPD3	VGNC	VGNC:75037
Felis catus	NCAPD3	VGNC	VGNC:63731
Bos taurus	NCAPD3	VGNC	VGNC:31902
Rattus norvegicus	NCAPD3	RGD	RGD:1562176
Canis familiaris	NCAPD3	VGNC	VGNC:43640
Others	NCAPD3	NCBI