Setd1a - SET domain containing 1A Gene

Also Known as KMT2F; mNSC1; Nsccn1; mKIAA0339

Species: Mus musculus

Gene Type: protein coding
Gene ID: 233904

Summary

Predicted to enable beta-catenin binding activity and Histone Methyltransferase activity (H3-K4 specific). Involved in several processes, including histone H3-K4 methylation; regulation of chromatin organization; and regulation of erythrocyte differentiation. Acts upstream of or within positive regulation of neural precursor cell proliferation; positive regulation of stem cell proliferation; and stem cell population maintenance. Located in euchromatin and nucleus. Is expressed in several structures, including early conceptus; integumental system; liver; nervous system; and oocyte. Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Setd1a Products (1)

mRNA Protein Name
NM_178029.3 NP_821172.2 histone-lysine N-methyltransferase SETD1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3K4 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
24550110 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
29490266 MGI
Biological Process GO Annotation Evidence References Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
31197650 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
27141965 MGI
acts upstream of or within positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
24550110 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
24550110 MGI
involved in regulation of chromatin organization IDA
IDA: Inferred from direct assay
27141965 MGI
involved in regulation of erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
27141965 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
24550110 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
24550110 MGI
Cellular Component GO Annotation Evidence References Source
located in euchromatin IDA
IDA: Inferred from direct assay
22723415 MGI
located in nucleus IDA
IDA: Inferred from direct assay
24550110 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SETD1A

  • SET domain-containing protein 1A

  • non-selective cation channel 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12740 SETD1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19526 Setd1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26021 Setd1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Setd1a NCBI NCBI:9739