Sorbs2 - sorbin and SH3 domain containing 2 Gene

Also Known as Argbp2; nArgBP2; mKIAA0777; A530071H08; 2010203O03Rik; 9430041O17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234214

Summary

Enables protein domain specific binding activity. Acts upstream of or within Notch signaling pathway; acetylcholine receptor signaling pathway; and regulation of skeletal muscle acetylcholine-gated channel clustering. Located in plasma membrane and synapse. Is expressed in several structures, including alimentary system; brain; cardiovascular system; cranium; and foot bone. Orthologous to human SORBS2 (sorbin and SH3 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Sorbs2 Products (17)

mRNA Protein Name
NM_001205219.1 NP_001192148.1 sorbin and SH3 domain-containing protein 2 isoform 1
NM_001310707.1 NP_001297636.1 sorbin and SH3 domain-containing protein 2 isoform 3
NM_001310708.1 NP_001297637.1 sorbin and SH3 domain-containing protein 2 isoform 4
NM_001402663.1 NP_001389592.1 sorbin and SH3 domain-containing protein 2 isoform 5
NM_001402664.1 NP_001389593.1 sorbin and SH3 domain-containing protein 2 isoform 6
NM_001402665.1 NP_001389594.1 sorbin and SH3 domain-containing protein 2 isoform 7
NM_001402666.1 NP_001389595.1 sorbin and SH3 domain-containing protein 2 isoform 8
NM_001402667.1 NP_001389596.1 sorbin and SH3 domain-containing protein 2 isoform 9
NM_001402668.1 NP_001389597.1 sorbin and SH3 domain-containing protein 2 isoform 10
NM_001402669.1 NP_001389598.1 sorbin and SH3 domain-containing protein 2 isoform 11
NM_001402670.1 NP_001389599.1 sorbin and SH3 domain-containing protein 2 isoform 12
NM_001402671.1 NP_001389600.1 sorbin and SH3 domain-containing protein 2 isoform 13
NM_001402672.1 NP_001389601.1 sorbin and SH3 domain-containing protein 2 isoform 14
NM_001402673.1 NP_001389602.1 sorbin and SH3 domain-containing protein 2 isoform 15
NM_001402674.1 NP_001389603.1 sorbin and SH3 domain-containing protein 2 isoform 16
NM_001402675.1 NP_001389604.1 sorbin and SH3 domain-containing protein 2 isoform 9
NM_172752.4 NP_766340.4 sorbin and SH3 domain-containing protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26527617 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
21689717 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
23117660 MGI
acts upstream of or within acetylcholine receptor signaling pathway IGI
IGI: Inferred from genetic interaction
26527617 MGI
acts upstream of or within regulation of skeletal muscle acetylcholine-gated channel clustering IGI
IGI: Inferred from genetic interaction
26527617 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
21689717 MGI
located in synapse IDA
IDA: Inferred from direct assay
26527617 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sorbin and SH3 domain-containing protein 2

  • Arg/Abl-binding protein 2

  • Arg/Abl-interacting protein ArgBP2

  • arg-binding protein 2

  • arg/Abl-interacting protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13568 SORBS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21941 Sorbs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28458 Sorbs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sorbs2 NCBI NCBI:8470