Scn3b - sodium channel, voltage-gated, type III, beta Gene

Also Known as Scnb3; 1110001K16Rik; 4833414B02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 235281

Summary

Enables transmembrane transporter binding activity and voltage-gated Sodium Channel activity involved in cardiac muscle cell action potential. Involved in SA node cell action potential; positive regulation of heart rate; and regulation of atrial cardiac muscle cell membrane depolarization. Acts upstream of or within cardiac conduction and ventricular cardiac muscle cell action potential. Located in Z disc. Is expressed in several structures, including gut; nervous system; sensory organ; skeletal musculature; and urinary system. Used to study Brugada syndrome 7. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Scn3b Products (4)

mRNA Protein Name
NM_001083917.1 NP_001077386.1 sodium channel subunit beta-3 isoform a precursor
NM_001286614.1 NP_001273543.1 sodium channel subunit beta-3 isoform b
NM_001359700.1 NP_001346629.1 sodium channel subunit beta-3 isoform a precursor
NM_178227.4 NP_839941.1 sodium channel subunit beta-3 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
20042427 MGI
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
19351516 MGI
Biological Process GO Annotation Evidence References Source
involved in SA node cell action potential IMP
IMP: Inferred from mutant phenotype
19796257 MGI
acts upstream of or within cardiac conduction IMP
IMP: Inferred from mutant phenotype
19351516 MGI
involved in positive regulation of heart rate IMP
IMP: Inferred from mutant phenotype
19796257 MGI
involved in regulation of atrial cardiac muscle cell membrane depolarization IMP
IMP: Inferred from mutant phenotype
19796257 MGI
acts upstream of or within ventricular cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
19351516 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
17884088 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium channel subunit beta-3

  • brain and heart sodium channel beta 3 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12536 SCN3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21042 Scn3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27560 Scn3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn3b NCBI NCBI:55800