SCN3B - sodium voltage-gated channel beta subunit 3 Gene

Also Known as SCNB3; ATFB16; BRGDA7; HSA243396

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55800

About SCN3B

Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38): 11:123,629,188-123,654,624 (from NCBI)

This gene has 9 transcripts (splice variants), 206 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in brain (RPKM 50.6) and adrenal (RPKM 4.9).

Summary

Voltage-gated sodium channels are Transmembrane Glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the Sodium Channel beta subunit gene family, and influences the inactivation kinetics of the Sodium Channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

SCN3B Products (2)

mRNA	Protein	Name
NM_001040151.2	NP_001035241.1	sodium channel subunit beta-3 precursor
NM_018400.4	NP_060870.1	sodium channel subunit beta-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables sodium channel regulator activity	IDA IDA: Inferred from direct assay	20226894	GOA
enables sodium channel regulator activity	IMP IMP: Inferred from mutant phenotype	20042427	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	20042427	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in atrial cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	21051419	GOA
involved in cardiac muscle cell action potential involved in contraction	IMP IMP: Inferred from mutant phenotype	21051419	GOA
involved in cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	20042427	GOA
involved in membrane depolarization	IDA IDA: Inferred from direct assay	21051419	GOA
involved in membrane depolarization during action potential	IDA IDA: Inferred from direct assay	20042427	GOA
involved in membrane depolarization during action potential	IMP IMP: Inferred from mutant phenotype	21051419	GOA
involved in membrane depolarization during cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	21051419	GOA
involved in positive regulation of sodium ion transport	IDA IDA: Inferred from direct assay	20042427	GOA
involved in positive regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	21051419	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	20042427	GOA
involved in regulation of atrial cardiac muscle cell membrane depolarization	IMP IMP: Inferred from mutant phenotype	21051419	GOA
involved in regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	20042427	GOA
involved in regulation of ventricular cardiac muscle cell membrane depolarization	IMP IMP: Inferred from mutant phenotype	20042427	GOA
involved in sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	20226894	GOA
involved in ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	20042427	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	24567321	GOA
part of voltage-gated sodium channel complex	IDA IDA: Inferred from direct assay	20042427	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCN3B Protein Structure

V-set

0
100
200
215 a.a.

Protein Preferred Names	Protein Names
sodium channel subunit beta-3	sodium channel, voltage-gated, type III, beta subunit

SCN3B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SCN3B	Q9NY72	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	MARCHF2	Homo sapiens	Q9P0N8	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	TVP23B	Homo sapiens	Q9NYZ1	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	SFXN3	Homo sapiens	Q9BWM7	Anti Tag CoIP	33961781
Intra	SCN3B	Q9NY72	SFXN3	Homo sapiens	Q9BWM7	Anti Tag CoIP	28514442
Intra	SCN3B	Q9NY72	ARV1	Homo sapiens	Q9H2C2	Anti Tag CoIP	28514442
Intra	SCN3B	Q9NY72	ARV1	Homo sapiens	Q9H2C2	Anti Tag CoIP	33961781
Intra	SCN3B	Q9NY72	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	TMEM14A	Homo sapiens	Q9Y6G1	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	THSD7A	Homo sapiens	Q9UPZ6	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	FIS1	Homo sapiens	Q9Y3D6	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	ERG28	Homo sapiens	Q9UKR5	Anti Tag CoIP	33961781
Intra	SCN3B	Q9NY72	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	IER3IP1	Homo sapiens	Q9Y5U9	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	USE1	Homo sapiens	Q9NZ43	Validated Y2H	32296183
Intra	SCN3B	Q9NY72	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SCN3B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76634	SCN3B Protein, Human (HEK293, Fc)	Q9NY72 (M1-E159)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76635	SCN3B Protein, Human (HEK293, His)	Q9NY72 (F23-E159)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Brugada Syndrome 7	Atrial Fibrillation, Familial, 16 BRGDA7 ATFB16 Brugada Syndrome, Type 7
Familial Atrial Fibrillation	Atrial Fibrillation, Familial Atfb Atrial Fibrillation Autosomal Dominant Autosomal Dominant Atrial Fibrillation Auricular Fibrillation Atrial Fibrillation Atrial Fibrillation, Familial, 1
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Right Bundle Branch Block	Right Bundle Branch Block With Left Posterior Fascicular Block
Atrial Fibrillation	A-Fib Fibrillation, Atrial Af - [Atrial Fibrillation] Rapid Atrial Fibrillation A Fib - [Atrial Fibrillation]
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Dravet Syndrome	Severe Myoclonic Epilepsy Of Infancy Severe Myoclonic Epilepsy In Infancy Smei Epileptic Encephalopathy, Early Infantile, 6 DRVT Developmental And Epileptic Encephalopathy 6a Dee6a Eiee6 Developmental And Epileptic Encephalopathy, 6 Dee6 Developmental And Epileptic Encephalopathy 6 Early Infantile Epileptic Encephalopathy 6 Myoclonic Epilepsy, Severe, Of Infancy Sme Severe Myoclonus Epilepsy Of Infancy Borderline Smei Smeb Smeb-M Smeb-O Smeb-Sw Smei-Borderland Smei-Borderland More Than One Feature Smei-Borderland-Myoclonic Seizures Smei-Borderland-Spike Wave Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures ICEGTC Infantile Severe Myoclonic Epilepsy Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Sinoatrial Node Disease	Sa Node Sinuatrial Node Sinus Node Dysfunction
Long Qt Syndrome 3	LQT3 Long Qt Syndrome Type 3 Long Qt Syndrome-3 Qt Syndrome, Long, Type 3
Short Qt Syndrome	Sqts Familial Short Qt Syndrome
Sick Sinus Syndrome	Sinus Node Dysfunction Sinus Node Disease Sinus Node Infection Snd Sss Snd - [Sinus Node Dysfunction] Sinoatrial Node Dysfunction Sss - [Sick Sinus Syndrome] Sick Sinus Sick Sinus Tachycardia
Second-Degree Atrioventricular Block	Second-Degree Heart Block Second Degree Atrioventricular Block Second Degree Atrioventricular Heart Block Second Degree Heart Block Incomplete Atrioventricular Block, Second Degree Nos Second-Degree Block, Type 1 And 2 Atrioventricular Block, Type 1 And 2 Second Degree Incomplete Atrioventricular Block Av - [Atrioventricular] Block 2nd
Long Qt Syndrome 2	LQT2 Long Qt Syndrome, Acquired, Reduced Susceptibility To Long Qt Syndrome 1/2 Long Qt Syndrome 2/3 Long Qt Syndrome 2/5 Long Qt Syndrome 2, Acquired, Susceptibility To Long Qt Syndrome, Acquired, Reduced Long Qt Syndrome Type 2 Long Qt Syndrome 2/9 Lqt1/2 Lqt2/3 Lqt2/5 Lqt2/9 Susceptibility To Acquired Long Qt Syndrome 2 Long Qt Syndrome-2 Qt Syndrome, Long, Type 2 Long Qt Syndrome 1-2 Long Qt Syndrome 2-3 Long Qt Syndrome 2-5 Long Qt Syndrome 9
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Generalized Epilepsy With Febrile Seizures Plus	Gefs+ Genetic Epilepsy With Febrile Seizures Plus Generalized Epilepsy With Febrile Seizures-Plus Genetic Epilepsy With Febrile Seizures-Plus Epilepsy, Generalized, With Febrile Seizures Plus
Catecholaminergic Polymorphic Ventricular Tachycardia	Cpvt Catecholamine-Induced Polymorphic Ventricular Tachycardia Familial Polymorphic Ventricular Tachycardia Malignant Paroxysmal Ventricular Tachycardia Multifocal Ventricular Premature Beats Stress-Induced Polymorphic Ventricular Tachycardia Bidirectional Tachycardia Induced By Catecholamine Double Tachycardia Induced By Catecholamines Polymorphic Catecholergic Ventricular Tachycardia Syncopal Paroxysmal Tachycardia Bidirectional Tachycardia Induced By Catecholamines Fpvt Bidirectional Ventricular Tachycardia Induced By Catecholamine Polymorphic Ventricular Tachycardia Induced By Catecholamines Ventricular Tachycardia, Catecholaminergic Polymorphic Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 Familial Ventricular Tachycardia Multifocal Pvcs Multifocal Premature Ventricular Beats
Heart Conduction Disease	Conduction Disorder Of The Heart Heart Rhythm Disease
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Left Ventricular Noncompaction	Noncompaction Cardiomyopathy Left Ventricular Hypertrabeculation Lvnc Spongy Myocardium Isolated Noncompaction Of The Ventricular Myocardium Left Ventricular Myocardial Noncompaction Cardiomyopathy Fetal Myocardium Honeycomb Myocardium Hypertrabeculation Syndrome Left Ventricular Non-Compaction Lvht Non-Compaction Of The Left Ventricular Myocardium Ventricular Noncompaction, Left Non-Compaction Cardiomyopathy
Epilepsy, Idiopathic Generalized	Idiopathic Generalized Epilepsy Generalised Epilepsy Epilepsy, Generalized EIG Ige Epilepsy, Idiopathic Generalized, Susceptibility To, 1 Epilepsy, Idiopathic Generalized 1 Epilepsy, Idiopathic Generalized, Susceptibility To Epilepsy, Idiopathic, Generalized Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12536	SCN3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21042	Scn3b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27560	Scn3b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SCN3B	VGNC	VGNC:77064
Rattus norvegicus	SCN3B	RGD	RGD:621657
Mus musculus	SCN3B	MGD	MGI:1918882
Felis catus	SCN3B	VGNC	VGNC:64923
Bos taurus	SCN3B	VGNC	VGNC:34349
Canis familiaris	SCN3B	VGNC	VGNC:45919
Others	SCN3B	NCBI