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NTSR2 - neurotensin receptor 2 Gene

Also Known as NTR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23620

About NTSR2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:11,658,178-11,670,195 (from NCBI)

This gene has 1 transcript (splice variant), 79 orthologues and 15 paralogues. Restricted expression toward brain (RPKM 9.3).

Summary

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several Other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]

NTSR2 Products (5)

mRNA	Protein	Name
XM_005246156.4	XP_005246213.1	neurotensin receptor type 2 isoform X4
XM_017003738.2	XP_016859227.1	neurotensin receptor type 2 isoform X1
NM_012344.4	NP_036476.2	neurotensin receptor type 2
XM_006711877.4	XP_006711940.1	neurotensin receptor type 2 isoform X3
XM_006711876.5	XP_006711939.1	neurotensin receptor type 2 isoform X2

NTSR2 Protein Structure

7tm_1

0
100
200
300
410 a.a.

Protein Preferred Names	Protein Names
neurotensin receptor type 2	NT-R-2 levocabastine-sensitive neurotensin receptor neurotensin receptor, type 2

Related Diseases

Diseases	Alias
Alzheimer Disease 14	AD14 Alzheimer'S Disease 14 Alzheimer Disease-14 Alzheimer'S Disease 14, Late Onset
Conduct Disorder
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11845	DOTA-NT-20.3-IPBA	Modulator	/	Unkown
HY-RS09641	NTSR2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS09642	Ntsr2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09643	Ntsr2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NTSR2	MGD	MGI:108018
Canis familiaris	NTSR2	VGNC	VGNC:44015
Rattus norvegicus	NTSR2	RGD	RGD:70962
Macaca mulatta	NTSR2	VGNC	VGNC:75545
Bos taurus	NTSR2	VGNC	VGNC:32313
Others	NTSR2	NCBI