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CA14 - carbonic anhydrase 14 Gene

Also Known as CAXiV

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23632

About CA14

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:150,257,774-150,265,078 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues and 14 paralogues. Biased expression in brain (RPKM 3.3), skin (RPKM 1.4) and 12 other tissues.

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the Other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]

CA14 Products (1)

mRNA	Protein	Name
NM_012113.3	NP_036245.1	carbonic anhydrase 14 precursor

CA14 Protein Structure

Carb_anhydrase

0
100
200
300
337 a.a.

Protein Preferred Names	Protein Names
carbonic anhydrase 14	CA-XIV

Recombinant CA14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72867	Carbonic Anhydrase 14 Protein, Human (HEK293, His)	Q9ULX7/NP_036245.1 (A16-M290)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Malignant Gastric Teratoma	Malignant Teratoma Of Stomach Immature Gastric Teratoma
Malignant Gastric Germ Cell Tumor	Germ Cell Tumor Of The Stomach Germ Cell Tumour Of The Stomach Malignant Gastric Germ Cell Tumour
Intracranial Hypertension, Idiopathic	Pseudotumor Cerebri Idiopathic Intracranial Hypertension Benign Intracranial Hypertension Iih Benign Intracran. Hypt.
Gastric Teratoma	Teratoma Of Stomach
Osteopetrosis, Autosomal Recessive 3	Osteopetrosis With Renal Tubular Acidosis Marble Brain Disease OPTB3 Guibaud-Vainsel Syndrome Carbonic Anhydrase Ii Deficiency Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis Autosomal Recessive Osteopetrosis 3 Carbonic Anhydrase 2 Deficiency Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis Osteopetrosis Autosomal Recessive 3 Autosomal Recessive Osteopetrosis Type 3 Guibaud Vainsel Syndrome Mixed Rta Mixed Renal Tubular Acidosis Renal Tubular Acidosis Type 3 Carbonic Anhydrase Ii Deficiency Syndrome Carbonic Anhydrase Ii Variant Osteopetrosis, Autosomal Recessive, Type 3 Carbonic Anhydrase 2
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01767	CA14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CA14	MGD	MGI:1344341
Bos taurus	CA14	VGNC	VGNC:26652
Macaca mulatta	CA14	VGNC	VGNC:70489
Rattus norvegicus	CA14	RGD	RGD:1599277
Felis catus	CA14	VGNC	VGNC:60244
Canis familiaris	CA14	VGNC	VGNC:38609
Others	CA14	NCBI