2. Gene
  3. FLRT1 - fibronectin leucine rich transmembrane protein 1 Gene

FLRT1 - fibronectin leucine rich transmembrane protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SPG68

Gene ID: 23769 | Gene type: protein coding

About FLRT1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,035,931-64,119,171 (from NCBI)

This gene has 2 transcripts (splice variants), 253 orthologues, 22 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 4.3), adrenal (RPKM 3.2) and 14 other tissues.

Summary

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]

FLRT1 Products(2)

mRNA Protein Name
NM_001384466.1 NP_001371395.1 leucine-rich repeat transmembrane protein FLRT1
NM_013280.5 NP_037412.2 leucine-rich repeat transmembrane protein FLRT1

FLRT1 Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (54 - 80)

LRR_8

LRR_8: Leucine rich repeat (128 - 189)

LRR_8

LRR_8: Leucine rich repeat (199 - 260)

LRR_8

LRR_8: Leucine rich repeat (271 - 328)

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  • 674 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat transmembrane protein FLRT1

fibronectin-like domain-containing leucine-rich transmembrane protein 1

Recombinant FLRT1 Proteins

Cat. No. Product Name Accession Purity
HY-P70925 FLRT1 Protein, Human (504a.a, HEK293, His) Q9NZU1 (I21-P524) ≥95%
HY-P76347 FLRT1 Protein, Human (524a.a, HEK293, His) Q9NZU1 (M1-P524) ≥95%

Related Diseases

Diseases Alias
Spastic Paraplegia, Optic Atrophy, And Neuropathy

Spoan Syndrome

SPOAN

Spastic Paraplegia, Optic Atropy, And Neuropathy

Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome

Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Spastic Paraplegia 8, Autosomal Dominant

SPG8

Hereditary Spastic Paraplegia 8

Autosomal Dominant Spastic Paraplegia Type 8

Autosomal Dominant Spastic Paraplegia 8

Paraplegia, Spastic, Autosomal Dominant, Type 8
Spastic Paraplegia 6, Autosomal Dominant

SPG6

Fsp3

Hereditary Spastic Paraplegia 6

Autosomal Dominant Spastic Paraplegia Type 6

Spastic Paraplegia 6

Familial Spastic Paraplegia Autosomal Dominant 3

Familial Spastic Paraplegia, Autosomal Dominant, 3

Autosomal Dominant Familial Spastic Paraplegia Type 3

Autosomal Dominant Spastic Paraplegia 6

Spastic Paraplegia-6

Paraplegia, Spastic, Type 6
Spastic Ataxia 3
Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04984 FLRT1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FLRT1 VGNC VGNC:40904
Macaca mulatta FLRT1 VGNC VGNC:72675
Felis catus FLRT1 VGNC VGNC:62296
Mus musculus FLRT1 MGD MGI:3026647
Rattus norvegicus FLRT1 RGD RGD:1565152
Bos taurus FLRT1 VGNC VGNC:29038
Others FLRT1 NCBI