Brip1 - BRCA1 interacting protein C-terminal helicase 1 Gene

Also Known as OF; FACJ; Bach1; Fancj; 3110009N10Rik; 8030460J03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 237911

Summary

This gene encodes a member of the DEAH subfamily of DEAD box helicases. A similar protein in humans is both a DNA-dependent ATPase and a 5-prime-to-3-prime DNA helicase, and plays a role in the repair of DNA double stranded breaks through interaction with the breast cancer-associated tumor suppressor BRCA1. [provided by RefSeq, Feb 2011]

Brip1 Products (1)

mRNA Protein Name
NM_178309.2 NP_840094.1 Fanconi anemia group J protein homolog

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within chiasma assembly IMP
IMP: Inferred from mutant phenotype
26490168 MGI
acts upstream of or within double-strand break repair involved in meiotic recombination IMP
IMP: Inferred from mutant phenotype
26490168 MGI
acts upstream of or within homologous chromosome pairing at meiosis IMP
IMP: Inferred from mutant phenotype
26490168 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
26490168 MGI
acts upstream of or within meiotic DNA double-strand break processing involved in reciprocal meiotic recombination IMP
IMP: Inferred from mutant phenotype
26490168 MGI
acts upstream of or within seminiferous tubule development IMP
IMP: Inferred from mutant phenotype
26490168 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
26490168 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
26490168 MGI
acts upstream of or within spermatogonial cell division IMP
IMP: Inferred from mutant phenotype
26490168 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Fanconi anemia group J protein homolog

  • ATP-dependent RNA helicase BRIP1

  • BRCA1-associated C-terminal helicase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01623 BRIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20866 Brip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27381 Brip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brip1 NCBI NCBI:83990