Mgll - monoglyceride lipase Gene

Also Known as Mgl; Magl

Species: Mus musculus

Gene Type: protein coding

Gene ID: 23945

Summary

This gene encodes a monoglyceride Lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Mgll Products (9)

mRNA	Protein	Name
NM_001166249.2	NP_001159721.1	monoglyceride lipase isoform c
NM_001166250.2	NP_001159722.1	monoglyceride lipase isoform d
NM_001166251.2	NP_001159723.1	monoglyceride lipase isoform a
NM_001410533.1	NP_001397462.1	monoglyceride lipase isoform e
NM_001410534.1	NP_001397463.1	monoglyceride lipase isoform f
NM_001410535.1	NP_001397464.1	monoglyceride lipase isoform g
NM_001410536.1	NP_001397465.1	monoglyceride lipase isoform h
NM_001410537.1	NP_001397466.1	monoglyceride lipase isoform i
NM_011844.5	NP_035974.1	monoglyceride lipase isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables monoacylglycerol lipase activity	IDA IDA: Inferred from direct assay	18096503	MGI
enables monoacylglycerol lipase activity	IMP IMP: Inferred from mutant phenotype	20729846	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in acylglycerol catabolic process	IDA IDA: Inferred from direct assay	18096503	MGI
involved in acylglycerol catabolic process	IMP IMP: Inferred from mutant phenotype	20729846	MGI
involved in arachidonate metabolic process	IMP IMP: Inferred from mutant phenotype	20729846	MGI
acts upstream of or within long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	20657592	MGI
involved in monoacylglycerol catabolic process	IDA IDA: Inferred from direct assay	20554061	MGI
acts upstream of or within regulation of axon extension	IMP IMP: Inferred from mutant phenotype	20962221	MGI
involved in regulation of endocannabinoid signaling pathway	IMP IMP: Inferred from mutant phenotype	20729846	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	17700715	MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid	IDA IDA: Inferred from direct assay	22783023	MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid	IMP IMP: Inferred from mutant phenotype	22783023	MGI
involved in regulation of sensory perception of pain	IMP IMP: Inferred from mutant phenotype	17700715	MGI
involved in regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	17700715	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	20962221	MGI
is active in cerebellar climbing fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	22783023	MGI
is active in cerebellar climbing fiber to Purkinje cell synapse	IMP IMP: Inferred from mutant phenotype	22783023	MGI
located in cytosol	IDA IDA: Inferred from direct assay	18096503	MGI
located in membrane	IDA IDA: Inferred from direct assay	18096503	MGI
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	22783023	MGI
is active in parallel fiber to Purkinje cell synapse	IMP IMP: Inferred from mutant phenotype	22783023	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	22783023	MGI
located in synapse	IDA IDA: Inferred from direct assay	20962221	MGI
located in varicosity	IDA IDA: Inferred from direct assay	20962221	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
monoglyceride lipase	monoacylglycerol lipase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18540	KT109	Inhibitor	99.86%	Unkown
HY-124576	ABD-1970	Inhibitor	/	Unkown
HY-RS08409	MGLL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16868	Mgll Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23309	Mgll Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24917	Clec10a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mgll	NCBI	NCBI:11343