Pacsin2 - protein kinase C and casein kinase substrate in neurons 2 Gene

Also Known as SdpII

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23970

Summary

Enables cytoskeletal protein binding activity and lipid binding activity. Involved in cell projection morphogenesis; modulation of chemical synaptic transmission; and plasma membrane tubulation. Acts upstream of or within negative regulation of endocytosis. Located in caveola; cell-cell junction; and cytosol. Is extrinsic component of membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; aorta; eye; genitourinary system; and thymus. Orthologous to human PACSIN2 (protein kinase C and Casein Kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Apr 2022]

Pacsin2 Products (10)

mRNA Protein Name
NM_001159509.2 NP_001152981.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 1
NM_001159510.2 NP_001152982.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 1
NM_001358641.2 NP_001345570.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 2
NM_001358642.2 NP_001345571.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 3
NM_001358643.2 NP_001345572.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 4
NM_001358644.2 NP_001345573.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 3
NM_001411850.1 NP_001398779.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 1
NM_001411851.1 NP_001398780.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 1
NM_001411852.1 NP_001398781.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 4
NM_011862.4 NP_035992.1 protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytoskeletal protein binding IDA
IDA: Inferred from direct assay
11082044 MGI
enables lipid binding IDA
IDA: Inferred from direct assay
20188097 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11082044 MGI
Biological Process GO Annotation Evidence References Source
involved in cell projection morphogenesis IMP
IMP: Inferred from mutant phenotype
20188097 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
23918399 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
23918399 MGI
acts upstream of or within negative regulation of endocytosis IDA
IDA: Inferred from direct assay
11082044 MGI
involved in plasma membrane tubulation IMP
IMP: Inferred from mutant phenotype
20188097 MGI
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
21610094 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11082044 MGI
located in cytosol IDA
IDA: Inferred from direct assay
10431838 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23918399 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23918399 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
20188097 MGI
NOT located in trans-Golgi network IDA
IDA: Inferred from direct assay
11082044 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein kinase C and casein kinase substrate in neurons protein 2

  • Syndapin II

  • syndapin-2

  • syndapin-II

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09958 PACSIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22015 Pacsin2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28533 Pacsin2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pacsin2 NCBI NCBI:11252