Spry2 - sprouty RTK signaling antagonist 2 Gene

Also Known as sprouty2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24064

Summary

Predicted to enable protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in several processes, including negative regulation of cell differentiation; negative regulation of cell projection organization; and negative regulation of signal transduction. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; lung development; and negative regulation of signal transduction. Located in several cellular components, including cytoskeleton; cytosol; and nucleus. Is expressed in several structures, including alimentary system; branchial arch; future brain; genitourinary system; and limb. Used to study achalasia and intestinal pseudo-obstruction. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2). [provided by Alliance of Genome Resources, Apr 2022]

Spry2 Products (1)

mRNA Protein Name
NM_011897.3 NP_036027.1 protein sprouty homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular function inhibitor activity IMP
IMP: Inferred from mutant phenotype
15962011 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11585837 MGI
enables ubiquitin-protein transferase inhibitor activity IMP
IMP: Inferred from mutant phenotype
15962011 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: Inferred from mutant phenotype
10074434 MGI
acts upstream of or within bud elongation involved in lung branching IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of or within cell fate commitment IGI
IGI: Inferred from genetic interaction
15809037 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
15809037 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within establishment of mitotic spindle orientation IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
15809037 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
15809037 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
15809037 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
10074434 MGI
acts upstream of or within lung growth IDA
IDA: Inferred from direct assay
11287183 MGI
acts upstream of or within lung morphogenesis IDA
IDA: Inferred from direct assay
11287183 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
18508928 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of or within negative regulation of GTPase activity IDA
IDA: Inferred from direct assay
11585837 MGI
acts upstream of or within negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
16339969 MGI
acts upstream of or within negative regulation of Ras protein signal transduction IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18070883 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of cell projection organization IDA
IDA: Inferred from direct assay
18508928 MGI
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
25576668 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
11585837 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
15809037 MGI
involved in negative regulation of lens fiber cell differentiation IDA
IDA: Inferred from direct assay
29501879 MGI
acts upstream of or within negative regulation of neurotrophin TRK receptor signaling pathway IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
25576668 MGI
involved in positive regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15962011 MGI
acts upstream of or within respiratory system development IDA
IDA: Inferred from direct assay
11287183 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
15809037 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoskeleton IDA
IDA: Inferred from direct assay
18508928 MGI
located in cytosol IDA
IDA: Inferred from direct assay
18508928 MGI
located in membrane IDA
IDA: Inferred from direct assay
18508928 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18508928 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein sprouty homolog 2

  • sprouty homolog 2

  • spry-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13722 SPRY2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22827 Spry2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29342 Spry2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spry2 NCBI NCBI:10253