Spry4 - sprouty RTK signaling antagonist 4 Gene

Also Known as sprouty4; A030006O18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24066

Summary

Predicted to enable protein kinase inhibitor activity. Acts upstream of or within cellular response to Leukemia Inhibitory Factor and negative regulation of MAP kinase activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; germ layer; and nervous system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4). [provided by Alliance of Genome Resources, Apr 2022]

Spry4 Products (1)

mRNA Protein Name
NM_011898.3 NP_036028.2 protein sprouty homolog 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16339969 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
16339969 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein sprouty homolog 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-202699 SHOC2-RAS PPI-IN-1 Inhibitor 99.50% Unkown
HY-181889 KRAS G12C-IN-75 Inhibitor / Unkown
HY-RS13724 SPRY4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22828 Spry4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29343 Spry4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spry4 NCBI NCBI:81848