Adamts4 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 Gene

Also Known as ADMP-1; ADAM-TS4; ADAMTS-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 240913

Summary

This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active zinc-dependent aggrecanase enzyme that degrades cartilage. [provided by RefSeq, Jul 2016]

Adamts4 Products (1)

mRNA Protein Name
NM_172845.3 NP_766433.2 A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
23684986 MGI
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
15192113 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23684986 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within defense response to bacterium IGI
IGI: Inferred from genetic interaction
23684986 MGI
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
15192113 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 4

  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4

  • aggrecanase-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137430 Aldumastat Inhibitor 99.36% Phase 2
HY-160822 AGG-523 Inhibitor 99.32% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114996 ADAMTS-5 Inhibitor Inhibitor 99.59% Unkown
HY-101448 TMI-1 99.57% Unkown
HY-P10398 5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA 91.94% Unkown
HY-145061 ADAMTS-5-IN-3 Inhibitor 98.89% Unkown
HY-P5419A WAAG-3R TFA 99.75% Unkown
HY-153505 ADAMTS-4/5-IN-1 Inhibitor / Unkown
HY-P10468 5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 / Unkown
HY-P11846 ADA2 Ligand / Unkown
HY-RS00303 ADAMTS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00304 ADAMTS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18103 Adamts4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24577 Adamts4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992358 GSK2394002 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adamts4 NCBI NCBI:9507