ADA2
ADA2 is an ADAMTS4-binding peptide and imaging agent with a human ADAMTS4 Ka of 5.3 nM and reduced renal uptake compared to related tracers. ADA2 accumulates in dilated aortic regions in aortic aneurysm mouse models. ADA2 exhibits an in vivo safety profile. ADA2 can be used for the research of aortic aneurysm.
For research use only. We do not sell to patients.
- Formula: C68H118N26O28S2
- Molecular Weight:1811.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ADAMTS4 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 8 weeks old, Angiotensin-II-induced aortic aneurysm model)[1]
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Dosage:100 μCi
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Administration:i.v.; single dose
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Result:Exhibited the highest aortic aneurysm radioactivity uptake of 1.6% ID/g among tested tracers at 60 minutes post-injection.
Showed more pronounced uptake in the AA region.
Demonstrated low uptake in other major organs, including heart, liver, and lungs.
Chemical Information
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Molecular Weight 1811.95
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Formula C68H118N26O28S2
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Sequence
Gly-{Lys(PEG2-DOTA)}-Gly-Gly-Ser-Gly-Gly-Ser-cyclo(Cys-Ser-Arg-Arg-Gly-Cys) (Disulfide bridge: Cys9-Cys14)
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Sequence Shortening
G-{Lys(PEG2-DOTA)}-GGSGGS-cyclo(Cys-Ser-Arg-Arg-Gly-Cys) (Disulfide bridge: Cys9-Cys14)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ADA2 Related Classifications
HY-P11846 Related Classifications
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