2. Metabolic Enzyme/Protease
  3. ADAMTS
  4. ADA2

ADA2 is an ADAMTS4-binding peptide and imaging agent with a human ADAMTS4 Ka of 5.3 nM and reduced renal uptake compared to related tracers. ADA2 accumulates in dilated aortic regions in aortic aneurysm mouse models. ADA2 exhibits an in vivo safety profile. ADA2 can be used for the research of aortic aneurysm.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

ADA2

ADA2 Chemical Structure

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ADA2 Related Antibodies

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Description

ADA2 is an ADAMTS4-binding peptide and imaging agent with a human ADAMTS4 Ka of 5.3 nM and reduced renal uptake compared to related tracers. ADA2 accumulates in dilated aortic regions in aortic aneurysm mouse models. ADA2 exhibits an in vivo safety profile. ADA2 can be used for the research of aortic aneurysm[1].

IC50 & Target

ADAMTS4

 

In Vivo

[68Ga]ADA2 (100 μCi; i.v.; single dose) achieves optimal aortic aneurysm uptake of 1.6% ID/g in Angiotensin-II-induced AA mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 8 weeks old, Angiotensin-II-induced aortic aneurysm model)[1]
Dosage: 100 μCi
Administration: i.v.; single dose
Result: Exhibited the highest aortic aneurysm radioactivity uptake of 1.6% ID/g among tested tracers at 60 minutes post-injection.
Showed more pronounced uptake in the AA region.
Demonstrated low uptake in other major organs, including heart, liver, and lungs.
Molecular Weight

1811.95

Formula

C68H118N26O28S2
Sequence

Gly-{Lys(PEG2-DOTA)}-Gly-Gly-Ser-Gly-Gly-Ser-cyclo(Cys-Ser-Arg-Arg-Gly-Cys) (Disulfide bridge: Cys9-Cys14)
Sequence Shortening

G-{Lys(PEG2-DOTA)}-GGSGGS-cyclo(Cys-Ser-Arg-Arg-Gly-Cys) (Disulfide bridge: Cys9-Cys14)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ADA2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADA2ADA 2ADA-2ADAMTSAdamalysin-like metalloproteinase with thrombospondin motifshuman aortic aneurysm tissue slicesADAMTS4C57BL/6 miceaortic aneurysmmouse modelsrenal uptakeAngiotensin-II-induced AA mouse modelsInhibitorinhibitorinhibit

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ADA2
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HY-P11846
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