2. Gene
  3. Pde11a - phosphodiesterase 11A Gene

Pde11a - phosphodiesterase 11A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gm350; PDE11A1; 6330414F14Rik; A630086N24Rik

Gene ID: 241489 | Gene type: protein coding

About Pde11a

Chromosome 2: 75,819,485-76,169,118 reverse strand.GRCm39:CM000995.3

This gene has 3 transcripts (splice variants), 101 orthologues, 20 paralogues and is associated with 18 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable cGMP binding activity and cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in negative regulation of cAMP-mediated signaling; negative regulation of cGMP-mediated signaling; and signal transduction. Predicted to be located in perikaryon. Is expressed in axial skeleton and nervous system. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE11A (phosphodiesterase 11A). [provided by Alliance of Genome Resources, Apr 2022]

Pde11a Products(1)

mRNA Protein Name
NM_001081033.3 NP_001074502.1 dual 3',5'-cyclic-AMP and #NAME? phosphodiesterase 11A

Pde11a Protein Structure

GAF

GAF: smart00065 (216 - 379)

GAF

GAF: smart00065 (401 - 567)

PDEase_I

PDEase_I: pfam00233 (662 - 897)

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  • 933 a.a.
Protein Preferred Names Protein Names

dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

cAMP and cGMP phosphodiesterase 11A

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156434 PDE11A4-IN-1 Inhibitor / Unkown
HY-RS10202 PDE11A Human Pre-designed siRNA Set A / Unkown
HY-RS10203 Pde11a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10204 Pde11a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde11a NCBI NCBI:50940