A2M - A2m alpha-2-macroglobulin Gene

Also Known as Mam; A2m1; A2mb; A2maa; A2MAC1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24153

Summary

Enables endopeptidase inhibitor activity; identical protein binding activity; and neurotrophin binding activity. Involved in several processes, including acute inflammatory response; embryonic liver development; and luteinization. Located in extracellular space. Used to study hemolytic anemia and toxic shock syndrome. Biomarker of several diseases, including liver disease (multiple); membranous glomerulonephritis; osteonecrosis; peritonitis; and trypanosomiasis. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin). [provided by Alliance of Genome Resources, Apr 2022]

A2M Products (1)

mRNA Protein Name
NM_012488.2 NP_036620.2 alpha-2-macroglobulin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables brain-derived neurotrophic factor binding IDA
IDA: Inferred from direct assay
11813239 RGD
enables endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
19240864 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
94834 RGD
enables nerve growth factor binding IDA
IDA: Inferred from direct assay
11813239 RGD
Biological Process GO Annotation Evidence References Source
involved in acute inflammatory response to antigenic stimulus IEP
IEP: Inferred from expression pattern
6202298 RGD
involved in acute-phase response IEP
IEP: Inferred from expression pattern
2468362 RGD
involved in embryonic liver development IEP
IEP: Inferred from expression pattern
2450021 RGD
involved in luteinization IEP
IEP: Inferred from expression pattern
2479532 RGD
involved in negative regulation of endopeptidase activity IDA
IDA: Inferred from direct assay
19240864 RGD
involved in response to carbon dioxide IEP
IEP: Inferred from expression pattern
12042906 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
2436819 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
9446838 RGD
involved in response to prostaglandin E IEP
IEP: Inferred from expression pattern
6202298 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
2442306 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-2-macroglobulin

  • alpha-2-M

  • alpha-2-macroglobulin-P

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00010 A2M Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-CE00893 2M2PE-CoA / Unkown
HY-RS18322 A2m Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19112 Pzp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24800 A2m Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens A2M NCBI NCBI:2