Pak5 - p21 (RAC1) activated kinase 5 Gene

Also Known as Pak7; PAK-5; PAK-7; 2900083L08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 241656

About Pak5

Chromosome 2: 135,923,024-136,229,887 reverse strand.GRCm39:CM000995.3

This gene has 3 transcripts (splice variants), 214 orthologues, 35 paralogues and is associated with 9 phenotypes. Biased expression in CNS E18 (RPKM 6.8), cortex adult (RPKM 6.4) and 5 other tissues.

Summary

Enables protein serine/threonine kinase activity. Acts upstream of or within learning or memory; locomotory behavior; and negative regulation of extrinsic apoptotic signaling pathway. Located in mitochondrion. Is active in synapse. Is expressed in brain. Orthologous to human PAK5 (p21 (RAC1) activated kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Pak5 Products (3)

mRNA Protein Name
NM_172858.2 NP_766446.2 serine/threonine-protein kinase PAK 5
NM_001360384.1 NP_001347313.1 serine/threonine-protein kinase PAK 5
NM_001360382.1 NP_001347311.1 serine/threonine-protein kinase PAK 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12897128 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within learning IGI
IGI: Inferred from genetic interaction
18675265 MGI
acts upstream of or within locomotory behavior IGI
IGI: Inferred from genetic interaction
18675265 MGI
acts upstream of or within memory IGI
IGI: Inferred from genetic interaction
18675265 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12897128 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
12897128 MGI
is active in synapse IDA
IDA: Inferred from direct assay
24474471 MGI
is active in synapse IEP
IEP: Inferred from expression pattern
24474471 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak5 Protein Structure

CRIB_PAK_like

CRIB_PAK_like: cd01093 (8 - 54)

STKc_PAK5

STKc_PAK5: cd06658 (425 - 716)

  • 0
  • 200
  • 400
  • 600
  • 719 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 5

  • p21 (RAC1) activated kinase 7

  • p21 protein (Cdc42/Rac)-activated kinase 7

  • p21-activated kinase 5

  • p21-activated kinase 7

  • serine/threonine-protein kinase PAK 7

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15323 PRT062607 Hydrochloride Inhibitor 98.07% Unkown
HY-15324 PRT062607 acetate Inhibitor 99.83% Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak5 NCBI NCBI:57144