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Agtr2 - angiotensin II receptor, type 2 Gene

Also Known as AT2R; AT2-R; AT2R

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24182

About Agtr2

Primary_assembly X: 112,120,228-112,124,057 forward strand.mRatBN7.2:CM026994.1

This gene has 1 transcript (splice variant), 192 orthologues, 8 paralogues and is associated with 46 phenotypes. Biased expression in Adrenal (RPKM 176.), Uterus (RPKM 25.3) and 3 other tissues.

Summary

Predicted to enable angiotensin type II receptor activity. Involved in several processes, including aldosterone secretion; animal organ development; and regulation of secretion. Located in perinuclear region of cytoplasm and plasma membrane. Used to study chronic kidney disease; congenital diaphragmatic hernia; glomerulonephritis (multiple); hypertension (multiple); and meconium aspiration syndrome. Biomarker of several diseases, including asthma; congestive heart failure; glomerulosclerosis (multiple); hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Agtr2 Products (1)

mRNA	Protein	Name
NM_012494.4	NP_036626.1	type-2 angiotensin II receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables angiotensin type II receptor activity	IDA IDA: Inferred from direct assay	8227011	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16754789	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	21173078	RGD
involved in cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	17537984	RGD
involved in cerebellar cortex development	IMP IMP: Inferred from mutant phenotype	19682991	RGD
involved in dopamine biosynthetic process	IMP IMP: Inferred from mutant phenotype	20097214	RGD
involved in intracellular sodium ion homeostasis	IMP IMP: Inferred from mutant phenotype	16380540	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	11924718	RGD
involved in kidney morphogenesis	IMP IMP: Inferred from mutant phenotype	18495111	RGD
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	22184331	RGD
involved in negative regulation of icosanoid secretion	IMP IMP: Inferred from mutant phenotype	18799632	RGD
involved in negative regulation of norepinephrine secretion	IDA IDA: Inferred from direct assay	18670361	RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17537984	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22645419	RGD
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	19033105	RGD
involved in regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	14657020	RGD
involved in renin-angiotensin regulation of aldosterone production	IMP IMP: Inferred from mutant phenotype	21318332	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	18463192	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14657020	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Agtr2 Protein Structure

7tmA_AT2R

0
100
200
300
363 a.a.

Protein Preferred Names	Protein Names
type-2 angiotensin II receptor	AT2 AT2 receptor angiotensin II type 2 receptor angiotensin receptor 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00469	AGTR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00470	Agtr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00471	Agtr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agtr2	NCBI	NCBI:186