Agtr2 - angiotensin II receptor, type 2 Gene

Rattus norvegicus

Also known as AT2R; AT2-R; AT2R

Gene ID: 24182 | Gene type: protein coding

About Agtr2

Primary_assembly X: 112,120,228-112,124,057 forward strand.mRatBN7.2:CM026994.1

This gene has 1 transcript (splice variant), 192 orthologues, 8 paralogues and is associated with 46 phenotypes. Biased expression in Adrenal (RPKM 176.), Uterus (RPKM 25.3) and 3 other tissues.

Summary

Predicted to enable angiotensin type II receptor activity. Involved in several processes, including aldosterone secretion; animal organ development; and regulation of secretion. Located in perinuclear region of cytoplasm and plasma membrane. Used to study chronic kidney disease; congenital diaphragmatic hernia; glomerulonephritis (multiple); hypertension (multiple); and meconium aspiration syndrome. Biomarker of several diseases, including asthma; congestive heart failure; glomerulosclerosis (multiple); hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Agtr2 Products(1)

mRNA	Protein	Name
NM_012494.4	NP_036626.1	type-2 angiotensin II receptor

Agtr2 Protein Structure

7tmA_AT2R

0
100
200
300
363 a.a.

Protein Preferred Names

Protein Names

type-2 angiotensin II receptor

AT2	AT2 receptor
angiotensin II type 2 receptor	angiotensin receptor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS00469	AGTR2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS00470	Agtr2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS00471	Agtr2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agtr2	NCBI	NCBI:186

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