Eno1 - enolase 1 Gene

Also Known as Nne

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24333

Summary

Enables several functions, including heat shock protein binding activity; phosphopyruvate hydratase activity; and protein homodimerization activity. Involved in ERK1 and ERK2 cascade; canonical glycolysis; and cellular response to hypoxia. Located in several cellular components, including growth cone; membrane raft; and synaptic membrane. Part of phosphopyruvate hydratase complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (Enolase 1). [provided by Alliance of Genome Resources, Apr 2022]

Eno1 Products (2)

mRNA Protein Name
NM_001109908.1 NP_001103378.1 alpha-enolase
NM_012554.3 NP_036686.2 alpha-enolase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
14499952 RGD
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
21958194 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
7086434 RGD
enables phosphopyruvate hydratase activity IDA
IDA: Inferred from direct assay
7964722 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7964722 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
7964722 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
7086434 RGD
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
15459207 RGD
involved in canonical glycolysis IDA
IDA: Inferred from direct assay
15041191 RGD
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
15459207 RGD
involved in glycolytic process IDA
IDA: Inferred from direct assay
7964722 RGD
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
19433310 RGD
located in cell surface IDA
IDA: Inferred from direct assay
7964722 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
15459207 RGD
located in cytosol IDA
IDA: Inferred from direct assay
14499952 RGD
located in growth cone IDA
IDA: Inferred from direct assay
19433310 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
14499952 RGD
part of phosphopyruvate hydratase complex IDA
IDA: Inferred from direct assay
15041191 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
7964722 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
15041191 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-enolase

  • 2-phospho-D-glycerate hydro-lyase

  • enolase 1, (alpha)

  • enolase 1, alpha non-neuron

  • non-neural enolase

Recombinant Eno1 Proteins

Cat. No. Product Name Accession Purity
HY-P75253 Enolase 1/ENO1 Protein, Rat (His) Q5BJ93 (M1-K434) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108868 Mersalyl Inducer 89.25% Unkown

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131904 POMHEX 99.54% Unkown
HY-117778 SF2312 Inhibitor 95.0% Unkown
HY-131904A Hex Inhibitor 99.07% Unkown
HY-102062 Nω-Propyl-L-arginine Inhibitor 98.31% Unkown
HY-102062A Nω-Propyl-L-arginine hydrochloride Inhibitor 99.88% Unkown
HY-179578 SU212 / Unkown
HY-117778B SF2312 ammonium Inhibitor 98.0% Unkown
HY-RS16574 Eno1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162168 Anti-inflammatory agent 71 Inhibitor / Unkown
HY-RS04378 ENO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23007 Eno1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991972 Anti-ENO1 Antibody Inhibitor / Unkown
HY-P991973 HuL001 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eno1 NCBI NCBI:2023