ENO1 - enolase 1 Gene
Also Known as NNE; PPH; MPB1; ENO1L1; HEL-S-17
Species: Homo sapiens
About ENO1
This gene has 16 transcripts (splice variants), 309 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 213.0), esophagus (RPKM 188.5) and 25 other tissues.
Summary
This gene encodes alpha-enolase, one of three Enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-Myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
ENO1 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001201483.4 | NP_001188412.1 | c-myc promoter-binding protein-1 isoform MBP-1 |
| NM_001353346.3 | NP_001340275.1 | alpha-enolase isoform 3 |
| NM_001428.5 | NP_001419.1 | alpha-enolase isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables DNA-binding transcription repressor activity, RNA polymerase II-specific |
IDA
IDA: Inferred from direct assay
|
2005901 | GOA |
| enables GTPase binding |
IPI
IPI: Inferred from physical interaction
|
24337748 | GOA |
| enables RNA polymerase II transcription regulatory region sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
2005901 | GOA |
| enables phosphopyruvate hydratase activity |
IDA
IDA: Inferred from direct assay
|
29775581 | GOA |
| enables phosphopyruvate hydratase activity |
IMP
IMP: Inferred from mutant phenotype
|
3529090 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12666133 | GOA |
| enables protein homodimerization activity |
IDA
IDA: Inferred from direct assay
|
3529090 | GOA |
| enables transcription corepressor activity |
IDA
IDA: Inferred from direct assay
|
11134351 | GOA |
| enables transcription corepressor binding |
IPI
IPI: Inferred from physical interaction
|
11134351 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell cortex |
IDA
IDA: Inferred from direct assay
|
19433310 | GOA |
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
12666133 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
15459207 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
12666133 | GOA |
| located in membrane |
IDA
IDA: Inferred from direct assay
|
19433310 | GOA |
| located in nuclear outer membrane |
IDA
IDA: Inferred from direct assay
|
11134351 | GOA |
| part of phosphopyruvate hydratase complex |
IDA
IDA: Inferred from direct assay
|
3529090 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
12666133 | GOA |
ENO1 Protein Structure
Enolase_N: Enolase, N-terminal domain (3 - 134)
Enolase_C: Enolase, C-terminal TIM barrel domain (143 - 431)
- 0
- 100
- 200
- 300
- 400
- 434 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
alpha-enolase c-myc promoter-binding protein-1 |
|
|
ENO1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ENO1 | P06733 | ACHE | Homo sapiens | P22303 | 18194455 | |
|
Intra
|
ENO1 | P06733 | YWHAZ | Homo sapiens | P63104 | 15324660 | |
|
Intra
|
ENO1 | P06733 | YWHAZ | Homo sapiens | P63104 | 23414517 | |
|
Intra
|
ENO1 | P06733 | YWHAZ | Homo sapiens | P63104 | 15161933 | |
|
Intra
|
ENO1 | P06733 | PCNA | Homo sapiens | P12004 | 20849852 | |
|
Intra
|
ENO1 | P06733 | PCNA | Homo sapiens | P12004 | 20849852 | |
|
Intra
|
ENO1 | P06733 | ENO3 | Homo sapiens | P13929 | 35271311 | |
|
Intra
|
ENO1 | P06733 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
ENO1 | P06733 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
ENO1 | P06733 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
ENO1 | P06733 | TTN | Homo sapiens | Q8WZ42 | 23414517 | |
|
Intra
|
ENO1 | P06733 | ENO2 | Homo sapiens | P09104 | 35271311 |
Recombinant ENO1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70260 | Enolase 1/ENO1 Protein, Human (His, solution) | P06733-1 (M1-K434) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70260A | Enolase 1/ENO1 Protein, Human (His) | P06733-1 (M1-K434) | ≥ 95%, as determined by reducing SDS-PAGE. |
ENO1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80655 | ENO1 Antibody (YA773) | WB | Human, Mouse, Rat, Monkey |
| HY-P80655A | ENO1 Antibody (YA773)(PBS only) | WB | Human, Mouse, Rat, Monkey |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hashimoto Encephalopathy |
|
|
| Cancer-Associated Retinopathy |
|
|
| Small Cell Carcinoma |
|
|
| Autoimmune Disease |
|
|
| Encephalopathy |
|
|
| Limbic Encephalitis |
|
|
| Keratoconus |
|
|
| Endometriosis |
|
|
| Hashimoto Thyroiditis |
|
|
| Giardiasis |
|
|
| Lung Cancer |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Iodine Hypothyroidism |
|
|
| Behcet Syndrome |
|
|
| Endocarditis |
|
|
| Liver Fibroma |
|
|
| Cardiac Arrest |
|
|
| Cryoglobulinemia, Familial Mixed |
|
|
| Systemic Lupus Erythematosus |
|
|
| Rheumatoid Arthritis |
|
|
| Esophagus Carcinoma In Situ |
|
|
| Skin Granular Cell Tumor |
|
|
| Interval Angle-Closure Glaucoma |
|
|
| Pancreatic Cancer |
|
|
| Autoimmune Pancreatitis |
|
|
| Ectodermal Dysplasia 5, Hair/Nail Type |
|
|
| Ectodermal Dysplasia 6, Hair/Nail Type |
|
|
| Ectodermal Dysplasia 7, Hair/Nail Type |
|
|
| Inflammatory Bowel Disease |
|
|
| Hepatocellular Carcinoma |
|
|
| Trombiculiasis |
|
|
| Breast Cancer |
|
|
| Prostate Cancer |
|
|
| Methylmalonic Aciduria, Cbla Type |
|
|
| Primary Biliary Cholangitis |
|
|
| Connective Tissue Disease |
|
|
| Cone-Rod Dystrophy 2 |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | ENO1 | MGD | MGI:95393 |
| Rattus norvegicus | ENO1 | RGD | RGD:2553 |
| Bos taurus | ENO1 | VGNC | VGNC:97268 |
| Canis familiaris | ENO1 | VGNC | VGNC:56009 |
| Felis catus | ENO1 | VGNC | VGNC:61865 |
| Others | ENO1 | NCBI |