Lrrtm4 - leucine rich repeat transmembrane neuronal 4 Gene

Also Known as A230052N11; 7530419J18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 243499

Summary

Enables heparan sulfate proteoglycan binding activity. Involved in regulation of synapse assembly. Acts upstream of or within AMPA glutamate receptor clustering; positive regulation of synapse assembly; and regulation of presynaptic membrane organization. Located in glutamatergic synapse and postsynaptic membrane. Part of AMPA glutamate receptor complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; and future midbrain. Orthologous to human LRRTM4 (leucine rich repeat transmembrane neuronal 4). [provided by Alliance of Genome Resources, Apr 2022]

Lrrtm4 Products (4)

mRNA Protein Name
NM_001134743.1 NP_001128215.1 leucine-rich repeat transmembrane neuronal protein 4 isoform 3 precursor
NM_001282102.1 NP_001269031.1 leucine-rich repeat transmembrane neuronal protein 4 isoform 2 precursor
NM_001347261.1 NP_001334190.1 leucine-rich repeat transmembrane neuronal protein 4 isoform 4 precursor
NM_178731.5 NP_848846.3 leucine-rich repeat transmembrane neuronal protein 4 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparan sulfate proteoglycan binding IDA
IDA: Inferred from direct assay
23911104 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within AMPA glutamate receptor clustering IMP
IMP: Inferred from mutant phenotype
23911104 MGI
acts upstream of or within neurotransmitter-gated ion channel clustering IDA
IDA: Inferred from direct assay
23911104 MGI
acts upstream of or within positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
24613359 MGI
acts upstream of or within regulation of presynaptic membrane organization IDA
IDA: Inferred from direct assay
23911104 MGI
involved in regulation of synapse assembly IDA
IDA: Inferred from direct assay
23911103 MGI
involved in regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
23911103 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
22632720 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
31974009 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23911103 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23911103 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
31974009 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
23911104 MGI
is active in synapse IDA
IDA: Inferred from direct assay
31974009 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeat transmembrane neuronal protein 4

Recombinant Lrrtm4 Proteins

Cat. No. Product Name Accession Purity
HY-P77069 LRRTM4 Protein, Mouse (HEK293, His) Q80XG9-1 (Q31-K424) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07844 LRRTM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20175 Lrrtm4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26679 Lrrtm4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrtm4 NCBI NCBI:80059