Gh1 - growth hormone 1 Gene

Also Known as Gh; Ghb1; RNGHGP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24391

Summary

Enables hormone activity. Involved in several processes, including cellular response to alkaline pH; cellular response to thyroid hormone stimulus; and generation of neurons. Located in several cellular components, including collagen-containing extracellular matrix; mitochondrion; and secretory granule. Used to study isolated growth hormone deficiency and type 1 diabetes mellitus. Biomarker of congenital hypothyroidism; osteoporosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to several human genes including GH1 (growth hormone 1). [provided by Alliance of Genome Resources, Apr 2022]

Gh1 Products (1)

mRNA Protein Name
NM_001034848.2 NP_001030020.2 somatotropin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
17258692 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to alkaline pH IEP
IEP: Inferred from expression pattern
23639351 RGD
involved in cellular response to thyroid hormone stimulus IEP
IEP: Inferred from expression pattern
1730572 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
18208550 RGD
involved in lung alveolus development IMP
IMP: Inferred from mutant phenotype
18985281 RGD
involved in neuroblast proliferation IDA
IDA: Inferred from direct assay
19524466 RGD
involved in positive regulation of growth IMP
IMP: Inferred from mutant phenotype
8398130 RGD
involved in positive regulation of neurogenesis IDA
IDA: Inferred from direct assay
19524466 RGD
involved in positive regulation of steroid hormone biosynthetic process IDA
IDA: Inferred from direct assay
17023532 RGD
involved in regulation of response to nutrient levels IDA
IDA: Inferred from direct assay
17258692 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
18753332 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
9681512 RGD
involved in response to light stimulus IDA
IDA: Inferred from direct assay
19091612 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
19439817 RGD
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
9255605 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
19382144 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
2980232 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

somatotropin

  • growth hormone b1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D1515 FM1-84 98.92% Unkown
HY-W011410 4-Nitrophenyl β-D-mannopyranoside Substrate 98.50% Unkown
HY-P3056 GHRF, ovine / Unkown
HY-RS05408 GH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05580 Gnrhr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24406 Gh1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gh1 NCBI NCBI:2688